Technology Process of C16H18F2N4O
There total 12 articles about C16H18F2N4O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: N-ethyl-N,N-diisopropylamine
2: sodium hydride
3: Heating
4: sodium tetrahydroborate
5: Chiralpak 1A / ethanol; hexane / Resolution of racemate
6: zinc; hydrogenchloride / water
7: ChiralCel AD
8: rhodium(III) chloride; sodium periodate
9: nido-decaborane / methanol
10: hydrogenchloride / ethyl acetate
With
hydrogenchloride; sodium tetrahydroborate; sodium periodate; rhodium(III) chloride; nido-decaborane; sodium hydride; N-ethyl-N,N-diisopropylamine; zinc;
In
methanol; ethanol; hexane; water; ethyl acetate;
DOI:10.1016/j.bmcl.2013.07.061
- Guidance literature:
-
Multi-step reaction with 9 steps
1: sodium hydride
2: Heating
3: sodium tetrahydroborate
4: Chiralpak 1A / ethanol; hexane / Resolution of racemate
5: zinc; hydrogenchloride / water
6: ChiralCel AD
7: rhodium(III) chloride; sodium periodate
8: nido-decaborane / methanol
9: hydrogenchloride / ethyl acetate
With
hydrogenchloride; sodium tetrahydroborate; sodium periodate; rhodium(III) chloride; nido-decaborane; sodium hydride; zinc;
In
methanol; ethanol; hexane; water; ethyl acetate;
DOI:10.1016/j.bmcl.2013.07.061
- Guidance literature:
-
Multi-step reaction with 2 steps
1: nido-decaborane / methanol
2: hydrogenchloride / ethyl acetate
With
hydrogenchloride; nido-decaborane;
In
methanol; ethyl acetate;
DOI:10.1016/j.bmcl.2013.07.061