Technology Process of 2-[N-(tert-butoxycarbonyl)-1H-indol-2-yl]phenyl isocyanate
There total 3 articles about 2-[N-(tert-butoxycarbonyl)-1H-indol-2-yl]phenyl isocyanate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 12 h / Inert atmosphere; Reflux
2.1: lithium hydroxide / tetrahydrofuran; water / 12 h / 60 °C
2.2: 20 °C
3.1: diphenyl phosphoryl azide; triethylamine / toluene / 1.5 h / 100 °C / Inert atmosphere; Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); diphenyl phosphoryl azide; sodium carbonate; triethylamine; lithium hydroxide;
In
tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;
1.1: Suzuki-Miyaura coupling / 3.1: Curtius rearrangement;
DOI:10.1016/j.tet.2012.03.055
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 12 h / Inert atmosphere; Reflux
2.1: lithium hydroxide / tetrahydrofuran; water / 12 h / 60 °C
2.2: 20 °C
3.1: diphenyl phosphoryl azide; triethylamine / toluene / 1.5 h / 100 °C / Inert atmosphere; Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); diphenyl phosphoryl azide; sodium carbonate; triethylamine; lithium hydroxide;
In
tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;
1.1: Suzuki-Miyaura coupling / 3.1: Curtius rearrangement;
DOI:10.1016/j.tet.2012.03.055
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hydroxide / tetrahydrofuran; water / 12 h / 60 °C
1.2: 20 °C
2.1: diphenyl phosphoryl azide; triethylamine / toluene / 1.5 h / 100 °C / Inert atmosphere; Microwave irradiation
With
diphenyl phosphoryl azide; triethylamine; lithium hydroxide;
In
tetrahydrofuran; water; toluene;
2.1: Curtius rearrangement;
DOI:10.1016/j.tet.2012.03.055
