Febuxostat Descyano Impurity

Base Information

• Chemical Name: Febuxostat Descyano Impurity
• CAS No.: 1206550-99-3
• Molecular Formula: C₁₅H₁₇NO₃S
• Molecular Weight: 291.371
• Mol file: 1206550-99-3.mol

Synonyms:

Chemical Property of Febuxostat Descyano Impurity

Chemical Property:

• Melting Point: 192-194°C
• Boiling Point: 471.5±55.0 °C(Predicted)
• PKA: 1.30±0.37(Predicted)
• Density: 1.213±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

3-DescyanoFebuxostat ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Descyano Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Technology Process of Febuxostat Descyano Impurity

There total 1 articles about Febuxostat Descyano Impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate (144060-97-9) → 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid (1206550-99-3)

Guidance literature:

With sodium hydroxide; In water; acetone; at 55 ℃; for 2h;

DOI:10.1016/j.bmcl.2014.07.058

upstream raw materials:

ethyl 2-(4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate

Refernces