4-broMo-N-isobutylaniline

Base Information

• Chemical Name: 4-broMo-N-isobutylaniline
• CAS No.: 195968-92-4
• Molecular Formula: C₁₀H₁₄BrN
• Molecular Weight: 228.132
• Mol file: 195968-92-4.mol

Synonyms:

Chemical Property of 4-broMo-N-isobutylaniline

Chemical Property:

• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% purity ^*data from raw suppliers

4-Bromo-N-isobutylaniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-broMo-N-isobutylaniline

There total 3 articles about 4-broMo-N-isobutylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-isobutylaniline (588-47-6) → 4-bromo-N-(2-methylpropyl)aniline (195968-92-4)

Guidance literature:

With tetrabutylammomium bromide; copper(ll) bromide; In ethanol; at 25 ℃; regioselective reaction;

DOI:10.1080/00397911.2019.1598558

Reference yield: 59.0%

isobutyraldehyde (78-84-2) + 4-bromo-aniline (106-40-1) → 4-bromo-N-(2-methylpropyl)aniline (195968-92-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In methanol; dichloromethane; at 20 ℃;

DOI:10.1021/acs.orglett.9b01200

Reference yield:

aniline (62-53-3) → 4-bromo-N-(2-methylpropyl)aniline (195968-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 4 h / 20 °C

1.2: 20 °C

2.1: copper(ll) bromide; tetrabutylammomium bromide / ethanol / 25 °C

With tetrabutylammomium bromide; copper(ll) bromide; In ethanol; dichloromethane;

DOI:10.1080/00397911.2019.1598558

upstream raw materials:

N-isobutylaniline

aniline

isobutyraldehyde

4-bromo-aniline

Refernces

• 1、 Ke, Lei,Zhu, Guirong,Qian, Hui,Xiang, Guangya,Chen, Qin,Chen, Zhilong. "Catalytic Selective Oxidative Coupling of Secondary N-Alkylanilines: An Approach to Azoxyarene". supporting information. p. 4008 - 4013. Retrieved 2019/06/04.