4,5-DICHLORO-2-(2-OXOPROPYL)-3(2H)-PYRIDAZINONE

Base Information

• Chemical Name: 4,5-DICHLORO-2-(2-OXOPROPYL)-3(2H)-PYRIDAZINONE
• CAS No.: 130159-58-9
• Molecular Formula: C7H6Cl2N2O2
• Molecular Weight: 221.043
• Hs Code.: 2933998090
• Mol file: 130159-58-9.mol

Synonyms:4,5-DICHLORO-2-(2-OXOPROPYL)-3(2H)-PYRIDAZINONE;3(2H)-Pyridazinone, 4,5-dichloro-2-(2-oxopropyl)-;4,5-dichloro-2-(2-oxopropyl)-2,3-dihydropyridazin-3-one

Chemical Property of 4,5-DICHLORO-2-(2-OXOPROPYL)-3(2H)-PYRIDAZINONE

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

4,5-Dichloro-2-(2-oxopropyl)-2,3-dihydropyridazin-3-one tech ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-DICHLORO-2-(2-OXOPROPYL)-3(2H)-PYRIDAZINONE

There total 2 articles about 4,5-DICHLORO-2-(2-OXOPROPYL)-3(2H)-PYRIDAZINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4,5-dichloro-2H-pyridazin-3-one (932-22-9) + chloroacetone (78-95-5) → 4,5-Dichloro-2-(2-oxo-propyl)-2H-pyridazin-3-one (130159-58-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 2h;

DOI:10.1002/jhet.5570340436

Reference yield: 63.0%

4,5-dichloro-2H-pyridazin-3-one (932-22-9) + 4-bromo-3-oxo-butyric acid (27807-85-8) → 4,5-Dichloro-2-(2-oxo-propyl)-2H-pyridazin-3-one (130159-58-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1002/jhet.5570340436

Reference yield: 75.0%

4-amino-2,6-dichlorophenol (5930-28-9) + 4,5-Dichloro-2-(2-oxo-propyl)-2H-pyridazin-3-one (130159-58-9) → 5-(4-Amino-2,6-dichloro-phenoxy)-4-chloro-2-(2-oxo-propyl)-2H-pyridazin-3-one

Guidance literature:

With potassium carbonate; In acetonitrile; for 4h; Heating;

DOI:10.1002/jhet.5570340436

upstream raw materials:

4,5-dichloro-2H-pyridazin-3-one

chloroacetone

4-bromo-3-oxo-butyric acid

Refernces

• 1、 Cho, Su-Dong,Choi, Woo-Yong,Yoon, Yong-Jin. "Concurrent Alkylation-Methoxylation of 4,5-Dihalopyridazin-6-ones and Synthesis of 5-Halo-4-hydroxypyridazin-6-ones". . p. 1579 - 1582. Retrieved 2007/10/03.