Technology Process of dimethyl 3-methoxycarbonylmethyl-6,7-methylenedioxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2,3-dicarboxylate
There total 6 articles about dimethyl 3-methoxycarbonylmethyl-6,7-methylenedioxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2,3-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
various solvent(s);
at 205 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 59 percent / bromine / acetic acid / Ambient temperature
2: 79 percent / sodium borohydride / tetrahydrofuran / Ambient temperature
3: 83 percent / n-butyl-lithium / tetrahydrofuran / -78 - 20 °C
4: 1.) triethylamine, methanesulphonyl chloride, 2.) sodium sulphide / 1.) dichloromethane, 0 deg C, 1 h, 2.) DMSO, room temperature
5: aq. peracetic acid / CH2Cl2 / Ambient temperature
6: 21 percent / various solvent(s) / 2 h / 205 °C
With
peracetic acid; sodium sulfide; sodium tetrahydroborate; n-butyllithium; bromine; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; dichloromethane; acetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 83 percent / n-butyl-lithium / tetrahydrofuran / -78 - 20 °C
2: 1.) triethylamine, methanesulphonyl chloride, 2.) sodium sulphide / 1.) dichloromethane, 0 deg C, 1 h, 2.) DMSO, room temperature
3: aq. peracetic acid / CH2Cl2 / Ambient temperature
4: 21 percent / various solvent(s) / 2 h / 205 °C
With
peracetic acid; sodium sulfide; n-butyllithium; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; dichloromethane;