2-Chloro-1,3-benzenedicarboxylic acid

Base Information

• Chemical Name: 2-Chloro-1,3-benzenedicarboxylic acid
• CAS No.: 13049-16-6
• Molecular Formula: C8H5ClO4
• Molecular Weight: 200.578
• Mol file: 13049-16-6.mol

Synonyms:F9995-0297;2-chloro-isophthalic acid;Isophthalic acid,2-chloro;2-Chlor-isophthalsaeure;

Chemical Property of 2-Chloro-1,3-benzenedicarboxylic acid

Chemical Property:

• Melting Point: 223-223.5 °C(Solv: water (7732-18-5))
• Boiling Point: 412.6±30.0 °C(Predicted)
• PKA: 2.22±0.25(Predicted)
• PSA: 74.60000
• Density: 1.586±0.06 g/cm3(Predicted)
• LogP: 1.73640
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-Chloroisophthalicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-1,3-benzenedicarboxylic acid

There total 9 articles about 2-Chloro-1,3-benzenedicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-chloro-1,3-dicyanobenzene (28442-78-6) → 2,6-dicarboxychlorobenzene (13049-16-6)

Guidance literature:

With sulfuric acid; acetic acid; for 5h; Heating;

Reference yield: 30.0%

2,6-dimethyl-1-chlorobenzene (6781-98-2) → 2,6-dicarboxychlorobenzene (13049-16-6) + 2-chloro-3-methylbenzoic acid (15068-35-6)

Guidance literature:

With cobalt(II) acetate; acetic acid; sodium bromide; at 95 ℃; for 6.7h; under 760.051 Torr;

Reference yield:

2,6-dimethyl-1-chlorobenzene (6781-98-2) → 2,6-dicarboxychlorobenzene (13049-16-6) + 2-chloro-3-carboxybenzaldehyde + 2-chloro-3-methylbenzaldehyde (61563-28-8) + 2-chloro-3-methylbenzoic acid (15068-35-6)

Guidance literature:

With oxygen; potassium bromide; at 70 - 75 ℃; under 750.075 - 8250.83 Torr; Pressure; Autoclave;

upstream raw materials:

2,6-dimethyl-1-chlorobenzene

2-chloro-1,3-dicyanobenzene

Benzene-1-nitro-2,6-dicyano

2.6-dimethylphenol

Downstream raw materials:

1-(3-Acetyl-2-methylsulfanyl-phenyl)-ethanone oxime

1,3-diacetyl-2-methylthiobenzene

2-chloro-1,3-diacetylbenzene

2-Chloro-5-nitro-1,3-benzenedicarboxylic acid

Refernces

• 1、 Móczár, Ildikó,Peragovics, ágnes,Baranyai, Péter,Tóth, Klára,Huszthy, Péter. "Synthesis and fluorescence studies of novel bis(azacrown ether) type chemosensors containing an acridinone unit". body text. p. 2953 - 2960. Retrieved 2010/06/17.
• 2、 Shelly, Kevin P.,Venimadhavan, S.,Nagarajan, K.,Stewart, Ross. "General acid catalysis in the enolization of acetone". . p. 1274 - 1282. Retrieved 2007/10/02.