americanol A

Base Information

• Chemical Name: americanol A
• CAS No.: 119280-58-9
• Molecular Formula: C₁₈H₁₈O₆
• Molecular Weight: 330.337
• Mol file: 119280-58-9.mol

Synonyms:

Chemical Property of americanol A

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of americanol A

There total 5 articles about americanol A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-(3,4-dihydroxy-phenyl)-7-(2-methoxycarbonyl-vinyl)-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid methyl ester (228714-16-7) → americanol A (119280-58-9,133838-65-0)

Guidance literature:

3-(3,4-dihydroxy-phenyl)-7-(2-methoxycarbonyl-vinyl)-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid methyl ester; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 20 ℃; for 13h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2.5h;

DOI:10.3987/com-01-s(k)24

Reference yield: 60.0%

(E)-4-(3-hydroxyprop-1-en-1-yl)benzene-1,2-diol (3598-26-3) → isoamericanol A (366493-18-7) + americanol A (119280-58-9,133838-65-0)

Guidance literature:

With dihydrogen peroxide; horseradish peroxidase; In 1,4-dioxane; phosphate buffer; at 20 ℃; for 0.5h; pH=6.0;

DOI:10.3987/com-01-s(k)24

Reference yield:

americanin A triacetate (109028-22-0) → americanol A (119280-58-9,133838-65-0)

Guidance literature:

With sodium tetrahydroborate; cerium(III) chloride; sodium hydrogencarbonate; In methanol; for 3h; Ambient temperature;

DOI:10.1248/cpb.40.252

upstream raw materials:

americanin A triacetate

3-(3,4-dihydroxy-phenyl)-7-(2-methoxycarbonyl-vinyl)-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid methyl ester

(E)-4-(3-hydroxyprop-1-en-1-yl)benzene-1,2-diol

7-(2-carboxy-vinyl)-3-(3,4-dihydroxy-phenyl)-2,3-dihydro-benzo[1,4]dioxine-2-carboxylic acid

Downstream raw materials:

americanol A tetraacetate

Refernces

• 1、 Fukuyama,Hasegawa,Toda,Kodama,Okazaki. "Structures of americanol A and isoamericanol A having a neurotrophic property from the seeds of Phytolacca americana". . p. 252 - 254. Retrieved 2007/10/02.