(4-chlorophenyl)(1H-pyrrol-2-yl)methanone

Base Information

• Chemical Name: (4-chlorophenyl)(1H-pyrrol-2-yl)methanone
• CAS No.: 13169-71-6
• Molecular Formula: C11H8ClNO
• Molecular Weight: 205.644
• Hs Code.: 2933990090
• Mol file: 13169-71-6.mol

Synonyms:2-p-chlorobenzoylpyrrole;4-chlorophenyl pyrrol-2-yl ketone;

Chemical Property of (4-chlorophenyl)(1H-pyrrol-2-yl)methanone

Chemical Property:

• PSA: 32.86000
• LogP: 2.89910
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(4-Chlorophenyl)(1H-pyrrol-2-yl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-chlorophenyl)(1H-pyrrol-2-yl)methanone

There total 15 articles about (4-chlorophenyl)(1H-pyrrol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-[2-(4-Chloro-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrole (132371-47-2) → 2-(4-chlorobenzoyl)pyrrole (13169-71-6)

Guidance literature:

With tetrafluoroboric acid; mercury(II) oxide; In dimethyl sulfoxide; at 60 ℃; for 0.5h;

Reference yield: 100.0%

2-[2-(4-Chloro-phenyl)-benzo[1,3]oxathiol-2-yl]-1H-pyrrole (112816-54-3) → 2-(4-chlorobenzoyl)pyrrole (13169-71-6)

Guidance literature:

With tetrafluoroboric acid; mercury(II) oxide; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jo00245a022

Reference yield: 95.6%

2-bromo-1H-pyrrole (38480-28-3) + para-Chlorobenzyl alcohol (873-76-7) → 2-(4-chlorobenzoyl)pyrrole (13169-71-6)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium cerium (IV) nitrate; n-butyl(triphenyl)phosphonium bromide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; 2,8,9-trioxa-5-aza-1-borabicyclo[3.3.3]undecane; In N,N-dimethyl-formamide; at 80 ℃; for 3h; Reagent/catalyst; Solvent; Catalytic behavior; Inert atmosphere;

upstream raw materials:

N-(4-chlorobenzoyl)morpholine

pyrrole

(4-chlorophenyl)-(1H-pyrrol-3-yl)methanone

2-[2-(4-Chloro-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrole

Downstream raw materials:

2-chloro-1-[5-(4-chlorobenzoyl)-1H-pyrrol-3-yl]ethanone

ethyl {2-[(4-chlorophenyl)carbonyl]-1H-pyrrol-1-yl}acetate

11-(4-Chloro-phenyl)-5H-benzo[e]pyrrolo[1,2-a]azepine

5,10,15,20-tetra-(4-chlorophenyl)porphyrin

Refernces

• 1、 -. "Synthesis method of 2-aromatic acyl pyrrole compounds". Paragraph 0025-0028; 0045-0048. . Retrieved 2021/06/12.
• 2、 Guo, Zhiqiang,Wei, Xuehong,Hua, Yupeng,Chao, Jianbin,Liu, Diansheng. "Synthesis of 2-benzoylpyrrole derivatives via C-H functionalization adjacent to nitrogen of pyrrole". . p. 3919 - 3922. Retrieved 2015/06/08.