6,7-DIMETHOXY-2-METHYLQUINAZOLIN-4-OL

Base Information

• Chemical Name: 6,7-DIMETHOXY-2-METHYLQUINAZOLIN-4-OL
• CAS No.: 35241-23-7
• Molecular Formula: C11H12 N2 O3
• Molecular Weight: 220.228
• Mol file: 35241-23-7.mol

Synonyms:4(1H)-Quinazolinone,6,7-dimethoxy-2-methyl- (9CI); 6,7-Dimethoxy-2-methylquinazolin-4(3H)-one;6,7-Dimethoxy-2-methylquinazolin-4-ol; NSC 338200

Chemical Property of 6,7-DIMETHOXY-2-METHYLQUINAZOLIN-4-OL

Chemical Property:

• Vapor Pressure: 6.69E-06mmHg at 25°C
• Boiling Point: 377.6°C at 760 mmHg
• Flash Point: 182.1°C
• PSA: 64.47000
• Density: 1.29
• LogP: 1.66100
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

6,7-Dimethoxy-2-methylquinazolin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7-DIMETHOXY-2-METHYLQUINAZOLIN-4-OL

There total 23 articles about 6,7-DIMETHOXY-2-METHYLQUINAZOLIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

acetic anhydride (108-24-7) + 2-Amino-4,5-dimethoxybenzoic acid (5653-40-7) → 6,7-dimethoxy-2-methylquinazoline-4(3H)-one (35241-23-7)

Guidance literature:

acetic anhydride; 2-Amino-4,5-dimethoxybenzoic acid; for 4h; Heating;

With ammonium hydroxide; at 20 ℃; for 4h;

With sodium hydroxide; for 0.5h; Heating;

DOI:10.1055/s-2004-815949

Reference yield: 89.0%

methyl 2-amino-4,5-dimethoxybenzoate (26759-46-6) + acetonitrile (75-05-8,26809-02-9) → 6,7-dimethoxy-2-methylquinazoline-4(3H)-one (35241-23-7)

Guidance literature:

methyl 2-amino-4,5-dimethoxybenzoate; acetonitrile; With hydrogenchloride; In 1,4-dioxane; for 2.5h; High pressure; Sonication;

In 1,4-dioxane; at 60 - 100 ℃; for 15h;

DOI:10.1002/cmdc.201300522

Reference yield: 89.0%

2-iodo-4,5-dimethoxybenzoic acid (61203-48-3) + acetamidine hydrochloride (124-42-5) → 6,7-dimethoxy-2-methylquinazoline-4(3H)-one (35241-23-7)

Guidance literature:

2-iodo-4,5-dimethoxybenzoic acid; acetamidine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

With iron(III)-acetylacetonate; caesium carbonate; N,N`-dimethylethylenediamine; In N,N-dimethyl-formamide; Microwave irradiation; Inert atmosphere;

DOI:10.1039/b916124b

upstream raw materials:

6,7-dimethoxy-2-methyl-4H-benzo[d] [1,3]oxazin-4-one

C₂₂H₂₂N₄O₄S₂

6,7-dimethoxy-2-methylquinazoline-4(3H)-thione

methyl 2-amino-4,5-dimethoxybenzoate

Downstream raw materials:

4-chloro-6,7-dimethoxy-2-methylquinazoline

6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-methylquinazoline

4-(6,7-dimethoxy-2-methyl-quinazolin-4-yloxy)-phenylamine

6,7-dimethoxy-2-methyl-4-(4-nitro-phenoxy)-quinazoline

Refernces

• 1、 Samim, Sk. Abdus,Roy, Bivas Chandra,Nayak, Sourav,Kundu, Sabuj. "Cobalt-Catalyzed Tandem Transformation of 2-Aminobenzonitriles to Quinazolinones Using Hydration and Dehydrogenative Coupling Strategy". . p. 11359 - 11367. Retrieved 2020/10/12.
• 2、 Baska, Ferenc,Sipos, Anna,?rfi, Zoltán,Nemes, Zoltán,Dobos, Judit,Szántai-Kis, Csaba,Szabó, Eszter,Szénási, Gábor,Dézsi, László,Hamar, Péter,Cserepes, Mihály T.,Tóvári, József,Garamv?lgyi, Rita,Krekó, Marcell,?rfi, László. "Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases". supporting information. . Retrieved 2019/10/16.