N-<(S)-1-(o-hydroxyphenyl)ethyl>-N-<(S)-1-α-naphthylethyl> (S^S)-phenylsulfinamide

Base Information

• Chemical Name: N-<(S)-1-(o-hydroxyphenyl)ethyl>-N-<(S)-1-α-naphthylethyl> (S^S)-phenylsulfinamide
• CAS No.: 78347-74-7
• Molecular Formula: C₂₆H₂₅NO₂S
• Molecular Weight: 415.556
• Mol file: 78347-74-7.mol

Synonyms:

Chemical Property of N-<(S)-1-(o-hydroxyphenyl)ethyl>-N-<(S)-1-α-naphthylethyl> (S^S)-phenylsulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(S)-1-(o-hydroxyphenyl)ethyl>-N-<(S)-1-α-naphthylethyl> (S^S)-phenylsulfinamide

There total 18 articles about N-<(S)-1-(o-hydroxyphenyl)ethyl>-N-<(S)-1-α-naphthylethyl> (S^S)-phenylsulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-o-<1-((S)-1-α-naphtylethylamino)ethyl>phenol (77382-90-2) → N-<(S)-1-(o-hydroxyphenyl)ethyl>-N-<(S)-1-α-naphthylethyl> (SR)-phenylsulfinamide (78347-74-7,78477-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: tetrahydrofuran / 2.5 h / -78 °C

With thionyl chloride; In tetrahydrofuran;

Reference yield:

(S)-o-<1-((S)-1-α-naphtylethylamino)ethyl>phenol (77382-90-2) → N-<(S)-1-(o-hydroxyphenyl)ethyl>-N-<(S)-1-α-naphthylethyl> (SS)-phenylsulfinamide (78347-74-7,78477-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: tetrahydrofuran / 2.5 h / -78 °C

With thionyl chloride; In tetrahydrofuran;

Reference yield:

(S)-1-(1-Naphthyl)ethylamine (10420-89-0) → N-<(S)-1-(o-hydroxyphenyl)ethyl>-N-<(S)-1-α-naphthylethyl> (SR)-phenylsulfinamide (78347-74-7,78477-83-5)

Guidance literature:

Multi-step reaction with 4 steps

1: benzene / 4 h / Heating

2: diethyl ether; tetrahydrofuran / 5 h / 0 °C

3: 208 mg / SOCl₂, Et₃N / toluene / 4 h / 0 °C

4: 10 mg / tetrahydrofuran / 2.5 h / -78 °C

With thionyl chloride; triethylamine; In tetrahydrofuran; diethyl ether; toluene; benzene;

upstream raw materials:

(2R,4S)-3,4-dihydro-4-methyl-3-<(S)-1-α-naphthylethyl>-1,2,3-benzoxathiazine 2-oxide

(2S,4S)-3,4-dihydro-4-methyl-3-<(S)-1-α-naphthylethyl>-1,2,3-benzoxathiazine 2-oxide

(S)-o-<1-((S)-1-α-naphtylethylamino)ethyl>phenol

(S)-1-(1-Naphthyl)ethylamine

Downstream raw materials:

(R)-(+)-butyl phenyl sulfoxide

(S)-(-)-n-butyl phenyl sulfoxide

Refernces

• 1、 Hiroi, Kunio,Kitayama, Ryuichi,Sato, Shuko. "THE ACID-CATALYZED EPIMERIZATION AT THE SULFUR ATOM OF OPTICALLY ACTIVE 1,2,3-BENZOXATHIAZINE 2-OXIDE AND STEREOSPECIFICITY IN ITS NUCLEOPHILIC SUBSTITUTION". . p. 879 - 882. Retrieved 2007/10/02.