N-(R)-(+)-1-phenylethylmaleamic acid

Base Information

• Chemical Name: N-(R)-(+)-1-phenylethylmaleamic acid
• CAS No.: 33139-83-2
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol file: 33139-83-2.mol

Synonyms:

Chemical Property of N-(R)-(+)-1-phenylethylmaleamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(R)-(+)-1-phenylethylmaleamic acid

There total 2 articles about N-(R)-(+)-1-phenylethylmaleamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

maleic anhydride (108-31-6) + (R)-1-phenyl-ethyl-amine (3886-69-9) → N-(R)-(+)-1-phenylethylmaleamic acid (33139-83-2)

Guidance literature:

In diethyl ether; for 1h; Ambient temperature;

Reference yield:

maleic anhydride (108-31-6) + rac-methylbenzylamine (618-36-0) → N-(1-phenylethyl)maleamidic acid (33139-83-2,33139-84-3,108088-06-8,62561-81-3)

Guidance literature:

In acetone; Ambient temperature;

Reference yield: 78.0%

N-(1-phenylethyl)maleamidic acid (33139-83-2,33139-84-3,108088-06-8,62561-81-3) → N-(S)-(-)-α-Methylbenzylmaleimide (6129-15-3,60925-76-0,94132-27-1,89143-10-2)

Guidance literature:

With sodium acetate; acetic anhydride; at 90 ℃;

upstream raw materials:

maleic anhydride

rac-methylbenzylamine

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

N-(S)-(-)-α-Methylbenzylmaleimide

(R)-1-(1-phenylethyl)-1H-pyrrole-2,5-dione

3-(4-Methoxy-phenylamino)-1-(1-phenyl-ethyl)-pyrrolidine-2,5-dione

3-(4-Ethoxy-phenylamino)-1-(1-phenyl-ethyl)-pyrrolidine-2,5-dione

Refernces

• 1、 Mhaske, Santosh B.,Argade, Narshinha P.. "Base-induced alcoholysis of N-arylmaleimides: Facile in situ oxa-Michael addition to alkyl maleanilates: Two-step one-pot rapid access to alkoxysuccinic acids". . p. 863 - 870. Retrieved 2007/10/03.
• 2、 Baldwin,Greenspan,Alaimo,McPhail. "Diastereoselective Diels-Alder reactions between substituted 1,3-butadienes and N-α-methylbenzylmaleimide". . p. 5877 - 5880. Retrieved 2007/10/02.