Isoquinoline-5-sulfonic acid benzyl-(2-hydroxy-ethyl)-amide

Base Information

• Chemical Name: Isoquinoline-5-sulfonic acid benzyl-(2-hydroxy-ethyl)-amide
• CAS No.: 116970-54-8
• Molecular Formula: C₁₈H₁₈N₂O₃S
• Molecular Weight: 342.419
• Mol file: 116970-54-8.mol

Synonyms:

Chemical Property of Isoquinoline-5-sulfonic acid benzyl-(2-hydroxy-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoquinoline-5-sulfonic acid benzyl-(2-hydroxy-ethyl)-amide

There total 2 articles about Isoquinoline-5-sulfonic acid benzyl-(2-hydroxy-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

isoquinoline-5-sulfonyl chloride hydrochloride (105627-79-0) + N-Benzylethanolamine (104-63-2) → Isoquinoline-5-sulfonic acid benzyl-(2-hydroxy-ethyl)-amide (116970-54-8)

Guidance literature:

With sodium hydrogencarbonate; 1) H₂O, 2) CHCl₃, RT, 1 h;

DOI:10.1021/jm00121a010

Reference yield:

isoquinoline-5-sulfonic acid (27655-40-9) → Isoquinoline-5-sulfonic acid benzyl-(2-hydroxy-ethyl)-amide (116970-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / SOCl₂, DMF / 2 h / Heating

2: 63 percent / NaHCO₃ / 1) H₂O, 2) CHCl₃, RT, 1 h

With thionyl chloride; sodium hydrogencarbonate; N,N-dimethyl-formamide;

DOI:10.1021/jm00121a010

Reference yield:

Isoquinoline-5-sulfonic acid benzyl-(2-hydroxy-ethyl)-amide (116970-54-8) → Isoquinoline-5-sulfonic acid (2-amino-ethyl)-benzyl-amide; hydrochloride (116970-88-8)

Guidance literature:

With phthalimide; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; Yield given. Multistep reaction; 1) THF, RT, overnight, 2) EtOH, reflux, 2 h;

DOI:10.1021/jm00121a010

upstream raw materials:

isoquinoline-5-sulfonyl chloride hydrochloride

N-Benzylethanolamine

isoquinoline-5-sulfonic acid

Downstream raw materials:

Isoquinoline-5-sulfonic acid (2-amino-ethyl)-benzyl-amide; hydrochloride

Refernces