Technology Process of 3,8-di(t-butyldimethylsilyloxy)-6-[4-[2-(1-piperidino)ethoxy]-phenyl]dibenzo[b,d]pyran
There total 6 articles about 3,8-di(t-butyldimethylsilyloxy)-6-[4-[2-(1-piperidino)ethoxy]-phenyl]dibenzo[b,d]pyran which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-[2-(4-bromophenoxy)ethyl]piperidine;
With
magnesium; ethylene dibromide;
In
tetrahydrofuran;
3,8-di(t-butyldimethylsilyloxy)-6-phenoxydibenzo[b,d]pyran;
In
tetrahydrofuran; toluene;
at 0 - 20 ℃;
for 28h;
DOI:10.1016/j.bmc.2004.02.018
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: imidazole / dimethylformamide
2.1: 620 mg / DIBAL-H / toluene; cyclohexane / 4 h / -95 - 20 °C
3.1: 210 mg / MgSO4 / CH2Cl2 / 4 h / 20 °C
4.1: Mg; 1,2-dibromoethane / tetrahydrofuran
4.2: 200 mg / tetrahydrofuran; toluene / 28 h / 0 - 20 °C
With
1H-imidazole; diisobutylaluminium hydride; magnesium sulfate; magnesium; ethylene dibromide;
In
tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2004.02.018
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 58 percent / NaOH; CuSO4 / Heating
2.1: imidazole / dimethylformamide
3.1: 620 mg / DIBAL-H / toluene; cyclohexane / 4 h / -95 - 20 °C
4.1: 210 mg / MgSO4 / CH2Cl2 / 4 h / 20 °C
5.1: Mg; 1,2-dibromoethane / tetrahydrofuran
5.2: 200 mg / tetrahydrofuran; toluene / 28 h / 0 - 20 °C
With
1H-imidazole; sodium hydroxide; diisobutylaluminium hydride; magnesium sulfate; copper(II) sulfate; magnesium; ethylene dibromide;
In
tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene;
1.1: Hurtley reaction;
DOI:10.1016/j.bmc.2004.02.018