phenyl(thieno[2,3-b]quinolin-2-yl)methanone

Base Information

• Chemical Name: phenyl(thieno[2,3-b]quinolin-2-yl)methanone
• CAS No.: 478260-43-4
• Molecular Formula: C₁₈H₁₁NOS
• Molecular Weight: 289.357
• Mol file: 478260-43-4.mol

Synonyms:

Chemical Property of phenyl(thieno[2,3-b]quinolin-2-yl)methanone

Chemical Property:

Purity/Quality:

PHENYL(THIENO[2,3-B]QUINOLIN-2-YL)METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl(thieno[2,3-b]quinolin-2-yl)methanone

There total 5 articles about phenyl(thieno[2,3-b]quinolin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-chloroquinolinyl ketone → phenyl(thieno[2,3-b]quinolin-2-yl)methanone (478260-43-4)

Guidance literature:

With sulfur; [2,2]bipyridinyl; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrabutylammonium acetate; copper; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Reagent/catalyst; Solvent; Temperature; Time;

DOI:10.1021/acs.orglett.9b04598

Reference yield:

2-oxo-2-phenylethylthiocyanate (5399-30-4) + 3-formyl-2-mercaptoquinoline (51925-41-8) → phenyl(thieno[2,3-b]quinolin-2-yl)methanone (478260-43-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.416667h;

DOI:10.1007/s11696-018-0497-4

Reference yield:

3-formyl-2-mercaptoquinoline (51925-41-8) + α-bromoacetophenone (70-11-1) → phenyl(thieno[2,3-b]quinolin-2-yl)methanone (478260-43-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.416667h;

DOI:10.1007/s11696-018-0497-4

upstream raw materials:

3-formyl-2-mercaptoquinoline

α-bromoacetophenone

2-chloro-3-quinoline carboxaldehyde

2-oxo-2-phenylethylthiocyanate

Refernces

• 1、 Nawaz Khan, Fazlur Rahman,Teja, Chitrala. "Facile Synthesis of 2-Acylthieno[2,3- b]quinolines via Cu-TEMPO-Catalyzed Dehydrogenation, sp2-C-H Functionalization (Nucleophilic Thiolation by S8) of 2-Haloquinolinyl Ketones". . p. 1726 - 1730. Retrieved 2020/03/24.