1,4-dimethyl-N-m-tolylcyclohex-3-enecarboxamide

Base Information

• Chemical Name: 1,4-dimethyl-N-m-tolylcyclohex-3-enecarboxamide
• CAS No.: 1427276-85-4
• Molecular Formula: C₁₆H₂₁NO
• Molecular Weight: 243.349
• Mol file: 1427276-85-4.mol

Synonyms:

Chemical Property of 1,4-dimethyl-N-m-tolylcyclohex-3-enecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-dimethyl-N-m-tolylcyclohex-3-enecarboxamide

There total 3 articles about 1,4-dimethyl-N-m-tolylcyclohex-3-enecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

1,4-Dimethyl-cyclohexen-(3)-carbonsaeure-(1)-chlorid (16695-96-8) + 1-amino-3-methylbenzene (108-44-1) → 1,4-dimethyl-N-m-tolylcyclohex-3-enecarboxamide (1427276-85-4)

Guidance literature:

In para-xylene; at 55 - 130 ℃; for 5h;

DOI:10.1134/S1070363213010325

Reference yield:

isoprene (78-79-5,9003-31-0) → 1,4-dimethyl-N-m-tolylcyclohex-3-enecarboxamide (1427276-85-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroquinone / toluene / 2 h / 180 - 200 °C

2: phosphorus trichloride

3: para-xylene / 5 h / 55 - 130 °C

With hydroquinone; phosphorus trichloride; In para-xylene; toluene; 1: |Diels-Alder Cycloaddition;

DOI:10.1134/S1070363213010325

Reference yield:

1,4-dimethylcyclohex-3-ene-1-carboxylic acid (16695-87-7) → 1,4-dimethyl-N-m-tolylcyclohex-3-enecarboxamide (1427276-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus trichloride

2: para-xylene / 5 h / 55 - 130 °C

With phosphorus trichloride; In para-xylene;

DOI:10.1134/S1070363213010325

upstream raw materials:

isoprene

1,4-Dimethyl-cyclohexen-⁽³⁾-carbonsaeure-⁽¹⁾-chlorid

1-amino-3-methylbenzene

1,4-dimethylcyclohex-3-ene-1-carboxylic acid

Refernces