Ciprofloxacin EP IMpurity D

Base Information

• Chemical Name: Ciprofloxacin EP IMpurity D
• CAS No.: 133210-96-5
• Molecular Formula: C17H18ClN3O3
• Molecular Weight: 0.00000
• European Community (EC) Number: 641-529-2
• UNII: UPG5846EWW
• ChEMBL ID: CHEMBL4061615
• Nikkaji Number: J760.362B
• Mol file: 133210-96-5.mol

Synonyms:133210-96-5;Ciprofloxacin EP Impurity D;7-CHLORO-1-CYCLOPROPYL-4-OXO-6-(PIPERAZIN-1-YL)-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID;UPG5846EWW;7-chloro-1-cyclopropyl-4-oxo-6-piperazin-1-ylquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid, 7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-6-(1-piperazinyl)-;UNII-UPG5846EWW;Ciprofloxacin impurity D [EP];SCHEMBL5549811;CHEMBL4061615;CIPROFLOXACIN IMPURITY D [EP IMPURITY];7-Chloro-1-cyclopropyl-4-oxo-6-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylicacid

Chemical Property of Ciprofloxacin EP IMpurity D

Chemical Property:

• Melting Point: >209°C (dec.)
• Boiling Point: 612.0±55.0 °C(Predicted)
• PKA: 6.41±0.41(Predicted)
• PSA: 0.00000
• Density: 1.483±0.06 g/cm3(Predicted)
• LogP: 0.00000
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 347.1036691
• Heavy Atom Count: 24
• Complexity: 571

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)Cl)N4CCNCC4)C(=O)O
• Uses: 7-Chloro-1-cyclopropyl-4-oxo-6-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride is an impurity in the synthesis of Ciprofloxacin (C482500), a fluorinated quinolone antibacterial.

Technology Process of Ciprofloxacin EP IMpurity D

There total 1 articles about Ciprofloxacin EP IMpurity D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

piperazine (110-85-0) + 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid (86393-33-1,178489-04-8) → ciprofloxacin (85721-33-1,178489-05-9,189257-90-7) + 1-cyclopropyl-7-chloro-6-piperazinyl-4-oxo-1,2-dihydroquinoline-3-carboxylic acid (133210-96-5)

Guidance literature:

In water; for 15h; Heating;

DOI:10.1515/HC.2005.11.5.415

upstream raw materials:

piperazine

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

Refernces

• 1、 Hermecz, Istvan,Vasvari-Debreczy, Lelle,Podanyi, Benjamin,Kereszturi, Geza,Balogh, Maria,Horvath, Agnes,Varkonyi, Peter. "Regioselective nucleophilic substitution of halogen derivatives of 1-substituted 4-oxo-1,4-dihydroquinoline-3-carboxylic acids". . p. 1111 - 1116. Retrieved 1998.