UNC0379 (trifluoroacetate)

Base Information

• Chemical Name: UNC0379 (trifluoroacetate)
• CAS No.: 1620401-83-3
• Molecular Formula: (x)C₂HF₃O₂*C₂₃H₃₅N₅O₂
• Molecular Weight: 527.59
• Mol file: 1620401-83-3.mol

Synonyms:

Chemical Property of UNC0379 (trifluoroacetate)

Chemical Property:

Purity/Quality:

>98% ^*data from raw suppliers

UNC0379trifluoroacetate >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of UNC0379 (trifluoroacetate)

There total 3 articles about UNC0379 (trifluoroacetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

pyrrolidine (123-75-1) + 2-chloro-6,7-dimethoxy-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine + trifluoroacetic acid (76-05-1) → 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine trifluoroacetic acid (1620401-83-3)

Guidance literature:

pyrrolidine; 2-chloro-6,7-dimethoxy-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine; With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 160 ℃; for 0.5h; Microwave irradiation;

trifluoroacetic acid; In methanol; water;

DOI:10.1021/jm500871s

Reference yield:

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one (27631-29-4) → 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine trifluoroacetic acid (1620401-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 0.5 h / 160 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; butan-1-ol;

DOI:10.1021/jm500871s

Reference yield:

5-(pyrrolidin-1-yl)pentan-1-amine (71302-71-1) → 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine trifluoroacetic acid (1620401-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 6 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 0.5 h / 160 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; butan-1-ol;

DOI:10.1021/jm500871s

upstream raw materials:

pyrrolidine

trifluoroacetic acid

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

5-(pyrrolidin-1-yl)pentan-1-amine

Refernces