5-ethyl-4-(piperazin-1-yl)pyrimidine

Base Information

• Chemical Name: 5-ethyl-4-(piperazin-1-yl)pyrimidine
• CAS No.: 1256492-23-5
• Molecular Formula: C₁₀H₁₆N₄
• Molecular Weight: 192.264
• Mol file: 1256492-23-5.mol

Synonyms:

Chemical Property of 5-ethyl-4-(piperazin-1-yl)pyrimidine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-Ethyl-4-(piperazin-1-yl)pyrimidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-ethyl-4-(piperazin-1-yl)pyrimidine

There total 4 articles about 5-ethyl-4-(piperazin-1-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl 4-(5-ethylpyrimidin-4-yl)piperazine-1-carboxylate → 5-ethyl-4-(piperazin-1-yl)pyrimidine (1256492-23-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

5-ethyl-pyrimidin-4-ol (25198-98-5) → 5-ethyl-4-(piperazin-1-yl)pyrimidine (1256492-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 21 °C

1.2: 48 h / 21 °C

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 21 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1042/BJ20101024

Reference yield:

tert-butyl 4-(5-bromopyrimidin-4-yl)piperazine-1-carboxylate → 5-ethyl-4-(piperazin-1-yl)pyrimidine (1256492-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,2-dimethoxyethane / 16 h / 95 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water;

upstream raw materials:

5-ethyl-pyrimidin-4-ol

Downstream raw materials:

PF-4708671

Refernces

• 1、 Pearce, Laura R.,Alton, Gordon R.,Richter, Daniel T.,Kath, John C.,Lingardo, Laura,Chapman, Justin,Hwang, Catherine,Alessi, Dario R.. "Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)". experimental part. p. 245 - 255. Retrieved 2011/10/19.