para-methoxyphenyl(trifluoromethyl)carbene

Base Information

• Chemical Name: para-methoxyphenyl(trifluoromethyl)carbene
• CAS No.: 1346414-73-0
• Molecular Formula: C₉H₇F₃O
• Molecular Weight: 188.149
• Mol file: 1346414-73-0.mol

Synonyms:

Chemical Property of para-methoxyphenyl(trifluoromethyl)carbene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of para-methoxyphenyl(trifluoromethyl)carbene

There total 3 articles about para-methoxyphenyl(trifluoromethyl)carbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trifluoro-1-(4-methoxyphenyl)-1-ethanone O-(p-tolylsulfonyl)oxime (300373-86-8) → para-methoxyphenyl(trifluoromethyl)carbene (1346414-73-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia / dichloromethane / 12 h / -78 °C

2: iodine; triethylamine / dichloromethane / 0 - 20 °C

3: -266.16 °C / Inert atmosphere; Irradiation; N₂ matrix

With ammonia; iodine; triethylamine; In dichloromethane;

DOI:10.1021/ja209613u

Reference yield:

3-(4-Methoxyphenyl)-3-(trifluoromethyl)diaziridine → para-methoxyphenyl(trifluoromethyl)carbene (1346414-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; triethylamine / dichloromethane / 0 - 20 °C

2: -266.16 °C / Inert atmosphere; Irradiation; N₂ matrix

With iodine; triethylamine; In dichloromethane;

DOI:10.1021/ja209613u

Reference yield:

3-(4-Methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine (891501-19-2) → para-methoxyphenyl(trifluoromethyl)carbene (1346414-73-0)

Guidance literature:

at -266.16 ℃; Inert atmosphere; Irradiation; N₂ matrix;

DOI:10.1021/ja209613u

upstream raw materials:

3-(4-Methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine

2,2,2-trifluoro-1-(4-methoxyphenyl)-1-ethanone O-(p-tolylsulfonyl)oxime

Downstream raw materials:

1-chloro-1-(4-methoxyphenyl)-2,2,2-trifluoroethane

Refernces

• 1、 Song, Myoung-Geun,Sheridan, Robert S.. "Regiochemical substituent switching of spin states in aryl(trifluoromethyl) carbenes". supporting information; experimental part. p. 19688 - 19690. Retrieved 2012/01/14.