Technology Process of (2α,5α,17β)-N-[2,5-bis(trifluoromethyl)phenyl]-2-iodo-3-oxo-4-aza-5-androstane-17-carboxamide
There total 8 articles about (2α,5α,17β)-N-[2,5-bis(trifluoromethyl)phenyl]-2-iodo-3-oxo-4-aza-5-androstane-17-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
2.1: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
3.1: triethylamine / acetonitrile / 4 h / -7 - -5 °C / Inert atmosphere
4.1: boron trifluoride diethyl etherate / acetonitrile / 4 h / -10 - -8 °C
5.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 1 h / -10 °C / Inert atmosphere; Large scale
5.2: 2 h / -10 - 0 °C / Large scale
With
chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; bromine; triethylamine; sodium hydroxide;
In
1,4-dioxane; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: boron trifluoride diethyl etherate / acetonitrile / 4 h / -10 - -8 °C
2.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 1 h / -10 °C / Inert atmosphere; Large scale
2.2: 2 h / -10 - 0 °C / Large scale
With
chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; boron trifluoride diethyl etherate;
In
dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / methanol / 0.58 h
2.1: hydrogen; palladium 10% on activated carbon; triethylamine / 6225.62 Torr
3.1: sodium hydroxide; bromine / water; 1,4-dioxane / 3 h / 5 - 7 °C
4.1: triethylamine / acetonitrile / 4 h / -7 - -5 °C / Inert atmosphere
5.1: boron trifluoride diethyl etherate / acetonitrile / 4 h / -10 - -8 °C
6.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 1 h / -10 °C / Inert atmosphere; Large scale
6.2: 2 h / -10 - 0 °C / Large scale
With
chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; bromine; toluene-4-sulfonic acid; triethylamine; sodium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; water; acetonitrile;