N-glycyl-L-phenylalanine benzyl ester; hydrobromide

Base Information

• Chemical Name: N-glycyl-L-phenylalanine benzyl ester; hydrobromide
• CAS No.: 87004-75-9
• Molecular Formula: BrH*C₁₈H₂₀N₂O₃
• Molecular Weight: 393.28
• Mol file: 87004-75-9.mol

Synonyms:

Chemical Property of N-glycyl-L-phenylalanine benzyl ester; hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-glycyl-L-phenylalanine benzyl ester; hydrobromide

There total 2 articles about N-glycyl-L-phenylalanine benzyl ester; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Gly-L-Phe-OBzl (24117-97-3) → N-glycyl-L-phenylalanine benzyl ester; hydrobromide (87004-75-9)

Guidance literature:

With hydrogen bromide; acetic acid;

DOI:10.1021/jo01366a011

Reference yield:

L-phenylalanine benzyl ester; hydrobromide → N-glycyl-L-phenylalanine benzyl ester; hydrobromide (87004-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl acetate; diethyl ether; aqueous KHCO₃

2: HBr; acetic acid

With diethyl ether; hydrogen bromide; potassium hydrogencarbonate; acetic acid; ethyl acetate;

DOI:10.1021/jo01366a011

Reference yield:

N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) + N-glycyl-L-phenylalanine benzyl ester; hydrobromide (87004-75-9) → N-benzyloxycarbonyl-glycyl=>glycyl=>phenylalanine benzyl ester; N-benzyloxycarbonyl-glycyl=>glycyl=>L-phenylalanine benzyl ester (34095-05-1)

Guidance literature:

With diethyl ether; potassium hydrogencarbonate; ethyl acetate;

DOI:10.1021/jo01366a011

upstream raw materials:

Z-Gly-L-Phe-OBzl

Downstream raw materials:

N-benzyloxycarbonyl-glycyl=>glycyl=>phenylalanine benzyl ester; N-benzyloxycarbonyl-glycyl=>glycyl=>L-phenylalanine benzyl ester