Technology Process of Phg-MePhe-Thz-OTmse
There total 9 articles about Phg-MePhe-Thz-OTmse which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / 72 h / 4 °C
2: 85 percent formic acid / 24 h / Ambient temperature
3: 46 percent / BopCl, NMM / tetrahydrofuran / 0 - 4 °C
4: 98 percent / 1.2 N aq. HCl / various solvent(s) / 1 h
5: 88 percent / BopCl, NMM / tetrahydrofuran / 48 h / 4 °C
6: 1 h
With
4-methyl-morpholine; hydrogenchloride; formic acid; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 88 percent / NaH / tetrahydrofuran / 0 deg C, 6 h, RT, overnight
2: 46 percent / BopCl, NMM / tetrahydrofuran / 0 - 4 °C
3: 98 percent / 1.2 N aq. HCl / various solvent(s) / 1 h
4: 88 percent / BopCl, NMM / tetrahydrofuran / 48 h / 4 °C
5: 1 h
With
4-methyl-morpholine; hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 46 percent / BopCl, NMM / tetrahydrofuran / 0 - 4 °C
2: 98 percent / 1.2 N aq. HCl / various solvent(s) / 1 h
3: 88 percent / BopCl, NMM / tetrahydrofuran / 48 h / 4 °C
4: 1 h
With
4-methyl-morpholine; hydrogenchloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride;
In
tetrahydrofuran;