Benzofuran, 2,3-dihydro-3-methyl-

Base Information

• Chemical Name: Benzofuran, 2,3-dihydro-3-methyl-
• CAS No.: 13524-73-7
• Molecular Formula: C9H10O
• Molecular Weight: 134.178
• Mol file: 13524-73-7.mol

Synonyms:3-methyl benzofuran;Benzofuran,2,3-dihydro-3-methyl;3-methyl-2,3-dihydrobenzofuran;3-methyl-dihydro benzofurane;2,3-dihydro-3-methylbenzofuran;2,3-dihydro-3-methylbenzofurane;

Chemical Property of Benzofuran, 2,3-dihydro-3-methyl-

Chemical Property:

• Boiling Point: 86-87 °C
• PSA: 9.23000
• Density: 1.035±0.06 g/cm3(Predicted)
• LogP: 2.18250

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzofuran, 2,3-dihydro-3-methyl-

There total 38 articles about Benzofuran, 2,3-dihydro-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-allyloxy-2-iodobenzene (24892-63-5) → 3-methyl-2,3-dihydrobenzofuran (13524-73-7) + allyl phenyl ether (1746-13-0)

Guidance literature:

With di-n-butyliodotin hydride; In hexane; at 25 ℃; Kinetics;

DOI:10.1002/chem.201406496

Reference yield: 67.0%

O-allyl-2-bromophenol (60333-75-7) → 3-methyl-2,3-dihydrobenzofuran (13524-73-7) + allyl phenyl ether (1746-13-0)

Guidance literature:

With C₈₄H₇₀N₆P₄; In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201505378

Reference yield: 47.0%

1-(2-(allyloxy)phenyl)-2-(tetrafluoro-λ5-boraneyl)diazene (25125-40-0) → 3-methyl-2,3-dihydrobenzofuran (13524-73-7) + allyl phenyl ether (1746-13-0)

Guidance literature:

β‐cyclodextrin; In water; at 25 ℃; pH 7.4, absence of air;

DOI:10.1246/cl.1991.337

upstream raw materials:

styrene

O-allyl-2-bromophenol

chromane

trans-2-Butene

Downstream raw materials:

2-isopropenylphenol

Refernces

• 1、 Boisvert, Guy,Giasson, Richard. "Induction of radical cyclizations with the 10-methyl-9,10-dihydroacridine / NaBH4 photocatalytic system". . p. 6587 - 6590. Retrieved 1992.
• 2、 Vaillard, Santiago E.,Postigo, Al,Rossi, Roberto A.. "Fast Tin-Free Hydrodehalogenation and Reductive Radical Cyclization Reactions: A New Reduction Process". . p. 2037 - 2041. Retrieved 2004.
• 3、 Yorimitsu, Hideki,Shinokubo, Hiroshi,Oshima, Koichiro. "Radical cyclization reaction using a combination of phosphinic acid and a base in aqueous ethanol". . p. 104 - 105. Retrieved 2000.
• 4、 Chernowsky, Colleen P.,Cowper, Nicholas G. W.,Wickens, Zachary K.,Williams, Oliver P.. "Potent Reductants via Electron-Primed Photoredox Catalysis: Unlocking Aryl Chlorides for Radical Coupling". supporting information. . Retrieved 2020/02/04.
• 5、 Hanson, Samuel S.,Doni, Eswararao,Traboulsee, Kyle T.,Coulthard, Graeme,Murphy, John A.,Dyker, C. Adam. "Pushing the Limits of Neutral Organic Electron Donors: A Tetra(iminophosphorano)-Substituted Bispyridinylidene". supporting information. p. 11236 - 11239. Retrieved 2016/07/06.