6-Methyl-1-aza-9H-carbazole

Base Information

• Chemical Name: 6-Methyl-1-aza-9H-carbazole
• CAS No.: 108349-67-3
• Molecular Formula: C₁₂H₁₀N₂
• Molecular Weight: 182.225
• Mol file: 108349-67-3.mol

Synonyms:

Chemical Property of 6-Methyl-1-aza-9H-carbazole

Chemical Property:

Purity/Quality:

98%,99% ^*data from raw suppliers

6-methyl-9H-Pyrido[2,3-b]indole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Methyl-1-aza-9H-carbazole

There total 13 articles about 6-Methyl-1-aza-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

8-(m-tolyl)tetrazolo[1,5-a]pyridine → 6-methyl-9H-pyrido[2,3-b]indole (108349-67-3)

Guidance literature:

With silver hexafluoroantimonate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; In benzene; at 130 ℃; for 24h; Sealed tube; Glovebox; Inert atmosphere;

DOI:10.1021/jacs.8b05343

Reference yield: 41.0%

→ 6-methyl-9H-pyrido[2,3-b]indole (108349-67-3)

Guidance literature:

With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine; In N,N-dimethyl acetamide; o-xylene; at 160 ℃; for 16h; Inert atmosphere;

Reference yield:

N-[2-(2-Chloro-pyridin-3-yl)-4-methyl-phenyl]-acetamide → 6-methyl-9H-pyrido[2,3-b]indole (108349-67-3)

Guidance literature:

With 18-crown-6 ether; sodium hydride; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1016/S0040-4039(00)60362-3

upstream raw materials:

5-methyl-1-pyridin-2-yl-1H-benzotriazole

phosphoric acid

2-bromo-4-methylacetanilide

2-aminopyridine

Refernces

• 1、 -. "CaMKII INHIBITORS AND USES THEREOF". Paragraph 00358-00362; 00368-00369. . Retrieved 2016/05/02.
• 2、 Achab, Said,Guyot, Michele,Potier, Pierre. "A short entry into the pyrido[2,3-b] indole ring system. Synthesis of the tetracyclic segment of the marine antitumor agents: Grossularines-1 and -2". . p. 2127 - 2130. Retrieved 2007/10/02.