Technology Process of 3-N,3'-O-bis(benzylomethyl)-2'-deoxy-5'-O-phosphonomethylthymidine diethyl ester
There total 5 articles about 3-N,3'-O-bis(benzylomethyl)-2'-deoxy-5'-O-phosphonomethylthymidine diethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ethyldiisopropylamine / 1 h / 50 °C
2: sodium methoxide / methanol / 1 h / Ambient temperature
3: 1.) sodium hydride / 1.) DMF, toluene, RT, 30 min, 2.) DMF, toluene, RT, 2 h
With
sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ethyldiisopropylamine / 1 h / 50 °C
2: sodium methoxide / methanol / 1 h / Ambient temperature
3: 1.) sodium hydride / 1.) DMF, toluene, RT, 30 min, 2.) DMF, toluene, RT, 2 h
With
sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium methoxide / methanol / 1 h / Ambient temperature
2: 1.) sodium hydride / 1.) DMF, toluene, RT, 30 min, 2.) DMF, toluene, RT, 2 h
With
sodium methylate; sodium hydride;
In
methanol;
