L-threo-fluoromalic acid

Base Information

• Chemical Name: L-threo-fluoromalic acid
• CAS No.: 74806-81-8
• Molecular Formula: C₄H₅FO₅
• Molecular Weight: 152.079
• Mol file: 74806-81-8.mol

Synonyms:

Chemical Property of L-threo-fluoromalic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of L-threo-fluoromalic acid

There total 1 articles about L-threo-fluoromalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

difluorofumaric acid (2714-32-1) → L-threo-fluoromalic acid (74806-81-8,34917-27-6)

Guidance literature:

With sodium formate; In water; for 24h; pH 7.2, NADH, formate dehydrogenase, malate dehydrogenase, fumarase;

DOI:10.1021/jo00389a035

Reference yield:

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + L-threo-fluoromalic acid (74806-81-8,34917-27-6) → (2R,3S)-2-Fluoro-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester (108150-00-1)

Guidance literature:

With pyridine; tetrachloromethane; for 1.25h;

DOI:10.1021/jo00389a035

upstream raw materials:

difluorofumaric acid

Downstream raw materials:

(2R,3S)-2-Fluoro-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester

Refernces