(Z)-α-Phenyl-N-butylnitrone

Base Information

• Chemical Name: (Z)-α-Phenyl-N-butylnitrone
• CAS No.: 27827-43-6
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• Mol file: 27827-43-6.mol

Synonyms:

Chemical Property of (Z)-α-Phenyl-N-butylnitrone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-α-Phenyl-N-butylnitrone

There total 9 articles about (Z)-α-Phenyl-N-butylnitrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-Benzyl-N-n-butylhydroxylamin (65616-28-6) → N-benzylidene-n-butylamine N-oxide (143957-78-2,27827-43-6)

Guidance literature:

With gold; oxygen; In methanol; at 60 ℃; for 2h; regioselective reaction;

DOI:10.1016/j.tet.2015.05.094

Reference yield: 85.0%

N-Benzyl-N-butylamine (2403-22-7) → N-benzylidene-n-butylamine N-oxide (143957-78-2,27827-43-6)

Guidance literature:

With dihydrogen peroxide; In methanol; at 60 ℃; for 6h; Reflux;

DOI:10.1039/c3dt53421a

Reference yield: 85.0%

(E)-N-benzylidenebutan-1-amine (57527-55-6) → (Z)-α-Phenyl-N-butylnitrone (27827-43-6,143957-78-2)

Guidance literature:

With urea hydrogen peroxide; methyltrioxorhenium(VII); In methanol; at 20 ℃; for 4h;

DOI:10.1021/ol062862w

upstream raw materials:

1-iodo-butane

Benzaldoxime

N-Benzyl-N-butylamine

benzaldehyde

Downstream raw materials:

2-butyl-3-phenyl-2,3-dihydrobenzo[d]isoxazole

N-n-butylhydroxylamine

benzaldehyde

Refernces

• 1、 Yudha S, Salprima,Kusuma, Indra,Asao, Naoki. "Aerobic oxidation of hydroxylamines with nanoporous gold catalyst as an efficient synthetic method of nitrones Dedicated to Professor Jiro Tsuji on the occasion of his receipt of the 2014 Tetrahedron Prize". . p. 6459 - 6462. Retrieved 2015/08/18.
• 2、 Nikbakht, Fatemeh,Heydari, Akbar,Saberi, Dariush,Azizi, Kobra. "Oxidation of secondary amines to nitrones using magnetically separable tungstophosphoric acid supported on silica-encapsulated γ-Fe 2O3 nanoparticles". . p. 6520 - 6523. Retrieved 2013/11/19.