Technology Process of (1R,2R)-2-(3,4-Dichloro-phenyl)-1-oxo-hexahydro-1λ4-thiopyran-2-carbothioic acid methylamide
There total 6 articles about (1R,2R)-2-(3,4-Dichloro-phenyl)-1-oxo-hexahydro-1λ4-thiopyran-2-carbothioic acid methylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 10 N aq. NaOH / 0.33 h / 70 °C
2: triethylbenzylammonium chloride, 10 N aq. NaOH / CH2Cl2 / Ambient temperature
3: m-chloroperoxybenzoic acid / CH2Cl2 / Ambient temperature
4: t-Bu0K / tetrahydrofuran / Ambient temperature
5: 1.) n-BuLi, HMPA / 1.) THF, -75 deg C, 1 h, 2.) THF, RT, 18 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00098a004
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylbenzylammonium chloride, 10 N aq. NaOH / CH2Cl2 / Ambient temperature
2: m-chloroperoxybenzoic acid / CH2Cl2 / Ambient temperature
3: t-Bu0K / tetrahydrofuran / Ambient temperature
4: 1.) n-BuLi, HMPA / 1.) THF, -75 deg C, 1 h, 2.) THF, RT, 18 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00098a004
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ethanol / 3 h / Heating
2: 10 N aq. NaOH / 0.33 h / 70 °C
3: triethylbenzylammonium chloride, 10 N aq. NaOH / CH2Cl2 / Ambient temperature
4: m-chloroperoxybenzoic acid / CH2Cl2 / Ambient temperature
5: t-Bu0K / tetrahydrofuran / Ambient temperature
6: 1.) n-BuLi, HMPA / 1.) THF, -75 deg C, 1 h, 2.) THF, RT, 18 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00098a004