2-Benzyl-2-cyclohexylmethyl-propanedioyl dichloride

Base Information

• Chemical Name: 2-Benzyl-2-cyclohexylmethyl-propanedioyl dichloride
• CAS No.: 174752-55-7
• Molecular Formula: C₁₇H₂₀Cl₂O₂
• Molecular Weight: 327.251
• Mol file: 174752-55-7.mol

Synonyms:

Chemical Property of 2-Benzyl-2-cyclohexylmethyl-propanedioyl dichloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyl-2-cyclohexylmethyl-propanedioyl dichloride

There total 4 articles about 2-Benzyl-2-cyclohexylmethyl-propanedioyl dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Benzyl-2-cyclohexylmethyl-malonic acid (136403-36-6) → 2-Benzyl-2-cyclohexylmethyl-propanedioyl dichloride (174752-55-7)

Guidance literature:

With calcium sulfate; thionyl chloride; at 60 ℃; for 4h;

DOI:10.1039/DT9920002679

Reference yield:

benzyl bromide (100-39-0) → 2-Benzyl-2-cyclohexylmethyl-propanedioyl dichloride (174752-55-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) NaH / 1) THF, rt, 2) reflux, 24 h

2: 1) NaH / 1) THF, rt, 4 h, 2) reflux, 24 h

3: aq. KOH / ethanol

4: SOCl₂, Drierite / 4 h / 60 °C

With calcium sulfate; potassium hydroxide; thionyl chloride; sodium hydride; In ethanol;

DOI:10.1039/DT9920002679

Reference yield:

2-Benzyl-2-cyclohexylmethyl-malonic acid diethyl ester (136403-35-5) → 2-Benzyl-2-cyclohexylmethyl-propanedioyl dichloride (174752-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / ethanol

2: SOCl₂, Drierite / 4 h / 60 °C

With calcium sulfate; potassium hydroxide; thionyl chloride; In ethanol;

DOI:10.1039/DT9920002679

upstream raw materials:

2-Benzyl-2-cyclohexylmethyl-malonic acid

benzyl bromide

2-Benzyl-2-cyclohexylmethyl-malonic acid diethyl ester

diethyl 2-benzylmalonate

Downstream raw materials:

2-Benzyl-2-cyclohexylmethyl-N,N'-di-quinolin-8-yl-malonamide

Refernces