Fortimicin A tetrahydrochloride

Base Information

• Chemical Name: Fortimicin A tetrahydrochloride
• CAS No.: 67010-18-8
• Molecular Formula: C₁₇H₃₅N₅O₆*4ClH
• Molecular Weight: 551.339
• Mol file: 67010-18-8.mol

Synonyms:

Chemical Property of Fortimicin A tetrahydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Fortimicin A tetrahydrochloride

There total 22 articles about Fortimicin A tetrahydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-O-benzyl-1,2',6',2''-tetra-N-benzyloxycarbonyl-2-epi-fortimicin A (76801-60-0) → 2-epi-fortimicin A tetrahydrochloride (67010-18-8,71564-66-4,71695-73-3,76420-54-7,76822-45-2,78738-61-1,78821-72-4,79703-13-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; for 4h; under 2280 Torr;

DOI:10.1016/S0008-6215(00)80393-6

Reference yield: 98.0%

1,2',6',2''-tetra-N-benzyloxycarbonyl-2-epi-fortimicin A (66962-56-9,71564-63-1,71873-76-2,73285-02-6,74742-44-2,76822-43-0,79703-12-1) → 2-epi-fortimicin A tetrahydrochloride (67010-18-8,71564-66-4,71695-73-3,76420-54-7,76822-45-2,78738-61-1,78821-72-4,79703-13-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; for 4h; under 2280 Torr;

DOI:10.1016/S0008-6215(00)80393-6

Reference yield:

1,2',6',2-tetra-N-benzyloxycarbonyl-6'-epi-fortimicin B (66962-56-9,71564-63-1,71873-76-2,73285-02-6,74742-44-2,76822-43-0,79703-12-1) → 6'-epi-fortimicin A (67010-18-8,71564-66-4,71695-73-3,76420-54-7,76822-45-2,78738-61-1,78821-72-4,79703-13-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 4h; under 2280 Torr;

DOI:10.1016/S0040-4020(01)92446-9

upstream raw materials:

1,2',6',2-tetra-N-benzyloxycarbonyl-6'-epi-fortimicin B

1,2'-di-N-benzyloxycarbonyl-6'-iminofortimicin B-4,5-carbamate

1,2'-di-N-benzyloxycarbonyl-6'-N-chlorofortimicin B-4,5-carbamate

1,2'-di-N-benzyloxycarbonyl-6'-N-(2,2,2-trichloroethoxycarbonyl)-fortimicin B-4,5-carbamate

Downstream raw materials:

6'-epi-fortimicin A disulfate

2-epi-fortimicin A disulfate

fortimicin A

fortimicin B

Refernces

• 1、 Tadanier, Jack,Hallas, Robert,Martin, Jerry R.,Cirovic, Momir,Stanaszek, Ruth S.. "PREPARATIONS OF 2-epi-FORTIMICINS A FROM 2-epi-FORTIMICIN B BY INTRAMOLECULAR BASE-CATALYZED 2-O-ACYLATION OF 1,2',6'-TRI-N-BENZYLOXYCARBONYL-2-EPI-FORTIMICIN B". . p. 207 - 218. Retrieved 2007/10/02.