erythrodiol

Base Information

• Chemical Name: erythrodiol
• CAS No.: 118204-21-0
• Molecular Formula: C₃₀H₅₀O₂
• Molecular Weight: 442.726
• Mol file: 118204-21-0.mol

Synonyms:

Chemical Property of erythrodiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythrodiol

There total 52 articles about erythrodiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Oleanolic acid (508-02-1) → erythrodiol (545-48-2,55869-95-9,118204-21-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.3390/molecules23071552

Reference yield: 95.0%

(3β)-3-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-olean-12-en-28-ol (152487-61-1) → erythrodiol (545-48-2,55869-95-9,118204-21-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 55 ℃; for 12h;

DOI:10.1021/ja00072a064

Reference yield: 85.0%

ursolic acid (77-52-1) → erythrodiol (545-48-2,55869-95-9,118204-21-0)

Guidance literature:

ursolic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Reflux;

With water; In tetrahydrofuran;

DOI:10.1134/S1068162011030101

upstream raw materials:

myricadiol

Oleanolic acid

oleanolic acid methyl ester

sodium ethanolate

Downstream raw materials:

erythrodiol diacetate

3β-acetoxy-28-hydroxy-ole-12-ene

28-O-acetylerythrodiol

11α,12α-epoxy-oleanan-28->13-olide-3β-yl acetate

Refernces

• 1、 Ren, Yulin,Anaya-Eugenio, Gerardo D.,Czarnecki, Austin A.,Ninh, Tran Ngoc,Yuan, Chunhua,Chai, Hee-Byung,Soejarto, Djaja D.,Burdette, Joanna E.,de Blanco, Esperanza J. Carcache,Kinghorn, A. Douglas. "Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives". . p. 4452 - 4460. Retrieved 2018.
• 2、 Narayanan,Natu. "". . p. 2639. Retrieved 1974.
• 3、 Rodriguez Hahn,L. et al.. "-". . p. 1735 - 1740. Retrieved 1965.
• 4、 Assefa, Haregewein,Nimrod, Alison,Walker, Larry,Sindelar, Robert. "Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid". . p. 1889 - 1894. Retrieved 1999.
• 5、 Ito, Aiko,Chai, Hee-Byung,Kardono, Leonardus B. S.,Setowati, Francisca M.,Afriastini, Johar J.,Riswan, Soedarsono,Farnsworth, Norman R.,Cordell, Geoffrey A.,Pezzuto, John M.,Swanson, Steven M.,Kinghorn, A. Douglas. "Saponins from the Bark of Nephelium maingayi". . p. 201 - 205. Retrieved 2004.
• 6、 Awashti,Y.C.,Mitra,C.R.. "-". . p. 637 - 640. Retrieved 1968.
• 7、 Tuncay, Salih,Senol, Halil,Guler, Eray Metin,Ocal, Nuket,Secen, Hasan,Kocyigit, Abdurrahim,Topcu, Gulacti. "Synthesis of oleanolic acid analogues and their cytotoxic effects on 3T3 cell line". . p. 617 - 625. Retrieved 2018/08/17.