N,N-Dimethyl-N'-(phenylsulfonyl)formamidine

Base Information

• Chemical Name: N,N-Dimethyl-N'-(phenylsulfonyl)formamidine
• CAS No.: 13707-43-2
• Molecular Formula: C9H12N2O2S
• Molecular Weight: 212.272
• DSSTox Substance ID: DTXSID001245542
• Nikkaji Number: J743.469C,J3.253.521F
• Mol file: 13707-43-2.mol

Synonyms:Maybridge1_003227;CBMicro_022629;Cambridge id 5492584;Oprea1_284207;SCHEMBL4110091;DTXSID001245542;N,N-Dimethyl-N'-(phenylsulfonyl)formamidine;N-[(dimethylamino)methylene]benzenesulfonamide;N-[(E)-(Dimethylamino)methylene]benzenesulfonamide;13707-43-2

Chemical Property of N,N-Dimethyl-N'-(phenylsulfonyl)formamidine

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 212.06194880
• Heavy Atom Count: 14
• Complexity: 284

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C)C=NS(=O)(=O)C1=CC=CC=C1

Technology Process of N,N-Dimethyl-N'-(phenylsulfonyl)formamidine

There total 21 articles about N,N-Dimethyl-N'-(phenylsulfonyl)formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(2,2,2-trichloroethylidene)benzenesulfonamide (55596-11-7) + complex of sulfur dioxide with dimethylamine (21326-49-8) → 1,1,2,2-tetrachloroethylene (127-18-4) + chloroform (67-66-3,8013-54-5) + N,N-dimethyl-N′-(phenylsulfonyl)formimidamide (13707-43-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

Reference yield: 98.0%

benzenesulfonamide (98-10-2) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → N,N-dimethyl-N′-(phenylsulfonyl)formimidamide (13707-43-2)

Guidance literature:

In neat (no solvent); at 20 ℃; for 0.25h; under 760.051 Torr; Solvent; Temperature; Green chemistry;

DOI:10.1039/c3gc40797g

Reference yield: 94.0%

benzenesulfonamide (98-10-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-dimethyl-N′-(phenylsulfonyl)formimidamide (13707-43-2)

Guidance literature:

With tert.-butylhydroperoxide; sodium iodide; In water; at 90 ℃; for 3h;

DOI:10.1021/ol2024604

upstream raw materials:

N,N-Dichlorobenzenesulfonamide

1,1-dichloromethyl-N,N-dimethylamine

N-(2,2,2-trichloroethylidene)benzenesulfonamide

complex of sulfur dioxide with dimethylamine

Refernces

• 1、 Jeong, Yuri,Ban, Jaeyoung,Lim, Minkyung,Rhee, Hakjune. "A Novel Synthesis of N -Sulfonylformamidines from N Sulfonyl sulfonamides". supporting information. p. 1867 - 1874. Retrieved 2018/02/26.
• 2、 Trillo, Paz,Slagbrand, Tove,Tinnis, Fredrik,Adolfsson, Hans. "Mild reductive functionalization of amides into N-sulfonylformamidines". . p. 484 - 487. Retrieved 2018/08/17.