4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol acetate

Base Information

• Chemical Name: 4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol acetate
• CAS No.: 1237512-84-3
• Molecular Formula: C₂H₄O₂*C₁₁H₁₇NO₃
• Molecular Weight: 271.313
• Mol file: 1237512-84-3.mol

Synonyms:

Chemical Property of 4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol acetate

There total 8 articles about 4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol (1237512-73-0) + acetic acid (64-19-7,77671-22-8) → 4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol acetate (1237512-84-3)

Guidance literature:

In methanol;

DOI:10.1002/ardp.200900218

Reference yield:

3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate (1237512-80-9) → 4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol acetate (1237512-84-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-dioxane; water / 20 h / Reflux

2: hydrazine hydrate; acetic acid / methanol / 3 h / Reflux

3: methanol

With hydrazine hydrate; acetic acid; In 1,4-dioxane; methanol; water;

DOI:10.1002/ardp.200900218

Reference yield:

2-[2-(4-acetyl-2,6-dimethylphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione (1237512-78-5) → 4-(2-aminopropoxy)-3-(hydroxymethyl)-5-methylphenol acetate (1237512-84-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Reflux

2: sodium metabisulfite; sodium bromate / cyclohexane; water; ethyl acetate / 20 °C

3: 1,4-dioxane; water / 20 h / Reflux

4: hydrazine hydrate; acetic acid / methanol / 3 h / Reflux

5: methanol

With sodium metabisulfite; sodium bromate; hydrazine hydrate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; dichloromethane; cyclohexane; water; ethyl acetate; 1: Baeyer-Villiger oxidation;

DOI:10.1002/ardp.200900218

upstream raw materials:

2-[2-(4-acetyl-2,6-dimethylphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione

4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-3,5-dimethylphenyl acetate

3-(bromomethyl)-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-5-methylphenyl acetate

2-{2-[4-hydroxy-2-(hydroxymethyl)-6-methylphenoxy]-1-methylethyl}-1H-isoindole-1,3(2H)-dione

Refernces