Technology Process of 5-Oxazolecarboxylic acid, 4-ethyl-2-phenyl-
There total 3 articles about 5-Oxazolecarboxylic acid, 4-ethyl-2-phenyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 32 percent / acetic acid / 3 h / Heating
2: 60 percent / KOH / ethanol; H2O / 48 h / Ambient temperature
3: 1.) LDA (lithium diisopropylamide) / 1.) THF, -35 deg C, 20 min, 2.) -> r.t.
With
potassium hydroxide; lithium diisopropyl amide;
In
ethanol; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 60 percent / KOH / ethanol; H2O / 48 h / Ambient temperature
2: 1.) LDA (lithium diisopropylamide) / 1.) THF, -35 deg C, 20 min, 2.) -> r.t.
With
potassium hydroxide; lithium diisopropyl amide;
In
ethanol; water;
- Guidance literature:
-
With
lithium diisopropyl amide;
Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
1.) THF, -35 deg C, 20 min, 2.) -> r.t.;
