Butanenitrile, 3-hydroxy-4-(phenylmethoxy)-

Base Information

• Chemical Name: Butanenitrile, 3-hydroxy-4-(phenylmethoxy)-
• CAS No.: 137618-52-1
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol file: 137618-52-1.mol

Synonyms:

Chemical Property of Butanenitrile, 3-hydroxy-4-(phenylmethoxy)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanenitrile, 3-hydroxy-4-(phenylmethoxy)-

There total 7 articles about Butanenitrile, 3-hydroxy-4-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-(benzyloxymethyl)-1,3-dioxo-2-thiolane 2-oxide (4704-76-1) + sodium cyanide (143-33-9,25596-52-5) → 4-(benzyloxy)-3-hydroxybutanenitrile (137618-52-1)

Guidance literature:

With tetrabutyl-ammonium chloride; In N,N-dimethyl-formamide; for 32h; Ambient temperature;

Reference yield: 80.0%

Benzyloxymethyl-oxiran (2930-05-4) + sodium cyanide (143-33-9,25596-52-5) → 4-(benzyloxy)-3-hydroxybutanenitrile (137618-52-1)

Guidance literature:

With sulfuric acid; In methanol; water; at 40 ℃; for 15h; pH=8 - 11;

DOI:10.1016/j.tetasy.2006.10.037

Reference yield: 79.0%

Benzyloxymethyl-oxiran (2930-05-4) → 4-(benzyloxy)-3-hydroxybutanenitrile (137618-52-1)

Guidance literature:

With potassium cyanide; In water; N,N-dimethyl-formamide; at 20 ℃; for 15h;

DOI:10.1021/jo902164z

upstream raw materials:

4-(benzyloxymethyl)-1,3-dioxo-2-thiolane 2-oxide

sodium cyanide

S-3,4-dihydroxy butyronitrile

iodomethylbenzene

Downstream raw materials:

(S)-4-(benzyloxy)-3-hydroxybutanenitrile

(3S)-4-(Benzyloxy)-3-(trimethylsilyloxy)butyronitrile

tert-butyl (S)-6-(benzyloxy)-5-hydroxy-3-oxohexanoate

3-(benzyloxymethyl)acrylonitrile

Refernces

• 1、 Surmont, Riccardo,Verniest, Guido,Thuring, Jan Willem,Macdonald, Gregor,Deroose, Frederik,De Kimpe, Norbert. "Synthesis of 4-substituted 3,3-difluoropiperidines". supporting information; experimental part. p. 929 - 932. Retrieved 2010/07/02.
• 2、 -. "Pyrimidine derivatives". . . Retrieved 2008/06/13.