p-Nitroclonidine

Base Information

• Chemical Name: p-Nitroclonidine
• CAS No.: 741202-17-5
• Molecular Formula: C₉H₈Cl₂N₄O₂
• Molecular Weight: 275.094
• Mol file: 741202-17-5.mol

Synonyms:

Chemical Property of p-Nitroclonidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-Nitroclonidine

There total 4 articles about p-Nitroclonidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(2,6-dichloro-4-nitrophenyl)carbonimidic dichloride (73218-65-2) + ethylenediamine (107-15-3,85404-18-8) → p-Nitroclonidine (65936-26-7,741202-17-5)

Guidance literature:

ethylenediamine; With triethylamine; In tetrahydrofuran; for 0.25h; Cooling with ice;

(2,6-dichloro-4-nitrophenyl)carbonimidic dichloride; In tetrahydrofuran; at 5 - 20 ℃; for 6.5h;

DOI:10.1080/00304948.2016.1206429

Reference yield:

4-nitro-2,6-dichloroaniline (99-30-9) → p-Nitroclonidine (65936-26-7,741202-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic anhydride / 0.33 h / 55 - 60 °C

1.2: 6.33 h / 55 °C

2.1: sulfuryl dichloride; thionyl chloride / 60 °C

3.1: triethylamine / tetrahydrofuran / 0.25 h / Cooling with ice

3.2: 6.5 h / 5 - 20 °C

With thionyl chloride; sulfuryl dichloride; acetic anhydride; triethylamine; In tetrahydrofuran;

DOI:10.1080/00304948.2016.1206429

Reference yield:

N-(2,6-dichloro-4-nitrophenyl)formamide (70106-94-4) → p-Nitroclonidine (65936-26-7,741202-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuryl dichloride; thionyl chloride / 60 °C

2.1: triethylamine / tetrahydrofuran / 0.25 h / Cooling with ice

2.2: 6.5 h / 5 - 20 °C

With thionyl chloride; sulfuryl dichloride; triethylamine; In tetrahydrofuran;

DOI:10.1080/00304948.2016.1206429

upstream raw materials:

(2,6-dichloro-4-nitrophenyl)carbonimidic dichloride

ethylenediamine

N-(2,6-dichloro-4-nitrophenyl)formamide

4-nitro-2,6-dichloroaniline

Downstream raw materials:

para-aminoclonidine

Refernces

• 1、 -. "Process for preparation of clonidine derivatives". . . Retrieved 2008/06/13.