GLYCYL-D-VALINE

Base Information

• Chemical Name: GLYCYL-D-VALINE
• CAS No.: 10521-49-0
• Molecular Formula: C7H14N2O3
• Molecular Weight: 174.2
• Hs Code.: 2924199090
• Mol file: 10521-49-0.mol

Synonyms:D-Valine,N-glycyl-;Valine, N-glycyl-, D- (8CI);Glycyl-D-valine;NSC 522444;

Chemical Property of GLYCYL-D-VALINE

Chemical Property:

• Vapor Pressure: 1.08E-07mmHg at 25°C
• Melting Point: 248ºC
• Refractive Index: 20 ° (C=2, H2O)
• Boiling Point: 405 °C at 760 mmHg
• PKA: 3.17±0.10(Predicted)
• Flash Point: 198.8 °C
• PSA: 92.42000
• Density: 1.168 g/cm³
• LogP: 0.26170
• Storage Temp.: -15°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Glycyl-D-valine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GLYCYL-D-VALINE

There total 2 articles about GLYCYL-D-VALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-Methyl-2-(2-phenylacetylamino-acetylamino)-butyric acid → phenylacetic acid (103-82-2) + glycyl-D-valine (10521-49-0,6491-59-4)

Guidance literature:

With sodium acetate; at 37 ℃; Rate constant; var. pH values;

DOI:10.1021/ja9804565

Reference yield:

N-glycyl-D-valine ethyl ester; hydrochloride (118864-66-7) → glycyl-D-valine (10521-49-0,6491-59-4)

Guidance literature:

With barium dihydroxide;

Reference yield:

{4-[(2R,3R)-3-[(RS)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-hydroxy-ethylsulfanyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenoxy}-acetic acid (917886-95-4) + glycyl-D-valine (10521-49-0,6491-59-4) → (R)-2-[2-(2-{4-[(2R,3R)-3-[(RS)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-hydroxy-ethylsulfanyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenoxy}-acetylamino)-acetylamino]-3-methyl-butyric acid

Guidance literature:

{4-[(2R,3R)-3-[(RS)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-hydroxy-ethylsulfanyl]-1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenoxy}-acetic acid; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 0.5h;

glycyl-D-valine; In N,N-dimethyl-formamide; for 16h;

upstream raw materials:

N-glycyl-D-valine ethyl ester; hydrochloride

Refernces