Sphydrofuran

Base Information

• Chemical Name: Sphydrofuran
• CAS No.: 33352-10-2
• Molecular Formula: C₈H₁₄O₅
• Molecular Weight: 190.196
• Mol file: 33352-10-2.mol

Synonyms:

Chemical Property of Sphydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Sphydrofuran

There total 1 articles about Sphydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-anhydro-2,3,5-tri-O-acetyl-4-C-(prop-2-enyl)-L-xylitol (143016-82-4) → sphydrofuran (11072-19-8) + Sphydrofuran (33352-10-2,143119-73-7) + (3R,4S,5S,8S)-1,7-Dioxa-spiro[4.5]decane-3,4,8-triol (143016-84-6,143062-52-6) + (3R,4S,5S,8R)-1,7-Dioxa-spiro[4.5]decane-3,4,8-triol (143016-84-6,143062-52-6)

Guidance literature:

With water; sodium methylate; palladium dichloride; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) THF, 2) MeOH;

DOI:10.1016/S0040-4039(00)92071-9

Reference yield:

Sphydrofuran (33352-10-2,143119-73-7) → 2,3-(Isopropylidenedioxy)-1-(5-methylfur-3-yl)propyl (R)-2-phenylbutyrate (137253-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 percent / malonic acid / 12 h / Ambient temperature

2: 35.5 percent / DCC, dimethylaminopyridine / 1 h / Ambient temperature

With dmap; malonic acid; dicyclohexyl-carbodiimide;

DOI:10.1002/hlca.19910740617

Reference yield:

Sphydrofuran (33352-10-2,143119-73-7) → 2,3-(Isopropylidenedioxy)-1-(5-methylfur-3-yl)propyl (S)-2-phenylbutyrate (137162-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 23 percent / malonic acid / 12 h / Ambient temperature

2: 30 percent / DCC, dimethylaminopyridine / 1 h / Ambient temperature

With dmap; malonic acid; dicyclohexyl-carbodiimide;

DOI:10.1002/hlca.19910740617

upstream raw materials:

1,4-anhydro-2,3,5-tri-O-acetyl-4-C-(prop-2-enyl)-L-xylitol

Downstream raw materials:

2,3-(Isopropylidenedioxy)-1-(5-methylfur-3-yl)propyl (R)-2-phenylbutyrate

2,3-(Isopropylidenedioxy)-1-(5-methylfur-3-yl)propyl (S)-2-phenylbutyrate

Refernces