1-(tert-butyl) 2-methyl (R)-4-oxopiperidine-1,2-dicarboxylate

Base Information

• Chemical Name: 1-(tert-butyl) 2-methyl (R)-4-oxopiperidine-1,2-dicarboxylate
• CAS No.: 1799811-83-8
• Molecular Formula: C₁₂H₁₉NO₅
• Molecular Weight: 257.287
• Hs Code.: 2933399990
• Mol file: 1799811-83-8.mol

Synonyms:

Chemical Property of 1-(tert-butyl) 2-methyl (R)-4-oxopiperidine-1,2-dicarboxylate

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95-99% ^*data from raw suppliers

(R)-1-tert-Butyl2-methyl4-oxopiperidine-1,2-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(tert-butyl) 2-methyl (R)-4-oxopiperidine-1,2-dicarboxylate

There total 16 articles about 1-(tert-butyl) 2-methyl (R)-4-oxopiperidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-1-(tertbutyloxycarbonyl)-4-oxo-piperidine-2-carboxylic acid (198646-60-5,661458-35-1) + methyl iodide (74-88-4) → 1-(tert-butyl)-2-methyl-(S)-4-oxopiperidine-1,2-dicarboxylate (1799811-83-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield: 99.0%

(2R)-1-(tert-butoxycarbonyl)-4-oxopiperidine-2-carboxylic acid (198646-60-5,661458-35-1) + methyl iodide (74-88-4) → methyl (R)-1-tert-butoxycarbonyl-4-oxopiperidine-2-carboxylate (1799811-83-8)

Guidance literature:

(2R)-1-(tert-butoxycarbonyl)-4-oxopiperidine-2-carboxylic acid; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 93.0%

4-Oxo-3,4-dihydro-2H-pyridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester → 4-oxo-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (81357-18-8,1799811-83-8)

Guidance literature:

With hydrogen; catalytic hydrogenation;

DOI:10.1016/S0040-4039(01)82993-2

upstream raw materials:

2-trimethylsilyloxy-1,3-butadiene

[(E)-tert-Butoxycarbonylimino]-acetic acid methyl ester

triphenyl(t-butoxycarbonylimino)phosphorane

N-tert-butoxycarbonyl-cis-4-hydroxy-L-pipecolinic acid methyl ester

Downstream raw materials:

C₂₀H₃₀N₂O₄

C₂₀H₃₀N₂O₄

C₂₆H₃₀N₂O₃

(2S,4S)-4-((but-2-yn-1-yl)methyl)amino-1-(2,2-diphenylacetyl)piperidine-2-carboxylic acid

Refernces

• 1、 -. "(R)-4-(1-(6-(4-(TRIFLUOROMETHYL)BENZYL)-6-AZASPIRO[2.5]OCTANE-5-CARBOXAMIDO)-CYCLOPROPYL) BENZOIC ACID OR ITS SALT ALSO IN POLYMORPHIC FORM A FOR USE IN THE PREVENTION OF HETEROTOPIC OSSIFICATION". Paragraph 0044-0046. . Retrieved 2021/06/03.
• 2、 -. "SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF". Paragraph 0339. . Retrieved 2019/10/15.