4-BroMo-5-(broMoMethyl)-3-Methylisoxazole

Base Information

• Chemical Name: 4-BroMo-5-(broMoMethyl)-3-Methylisoxazole
• CAS No.: 53257-36-6
• Molecular Formula: C₅H₅Br₂NO
• Molecular Weight: 254.909
• Mol file: 53257-36-6.mol

Synonyms:

Chemical Property of 4-BroMo-5-(broMoMethyl)-3-Methylisoxazole

Chemical Property:

Purity/Quality:

4-Bromo-5-(bromomethyl)-3-methylisoxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-BroMo-5-(broMoMethyl)-3-Methylisoxazole

There total 3 articles about 4-BroMo-5-(broMoMethyl)-3-Methylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5-(bromomethyl)-3-methyl-1,2-oxazole (36958-61-9) → 4-bromo-5-bromomethyl-3-methyl-isoxazole (53257-36-6)

Guidance literature:

With N-Bromosuccinimide; sulfuric acid; acetic acid; at 110 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201712065

Reference yield:

3-methyl-5-isoxazolemethanol (14716-89-3) → 4-bromo-5-bromomethyl-3-methyl-isoxazole (53257-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 4 h / -17 - 23 °C / Inert atmosphere

2: N-Bromosuccinimide; sulfuric acid; acetic acid / 1 h / 110 °C / Inert atmosphere

With N-Bromosuccinimide; carbon tetrabromide; sulfuric acid; acetic acid; triphenylphosphine; In dichloromethane;

DOI:10.1002/anie.201712065

Reference yield:

→ 4-bromo-5-bromomethyl-3-methyl-isoxazole (53257-36-6)

Guidance literature:

Brommethylisoxazol, Halogen;

upstream raw materials:

3-methyl-5-isoxazolemethanol

5-(bromomethyl)-3-methyl-1,2-oxazole

Downstream raw materials:

1-[2-(4-Bromo-3-methyl-isoxazol-5-ylmethoxy)-phenoxy]-3-isopropylamino-propan-2-ol

4-Bromo-3-methyl-5-(2-oxiranylmethoxy-phenoxymethyl)-isoxazole

2-(4-Bromo-3-methyl-isoxazol-5-ylmethoxy)-phenol

Refernces