(1-(4-methoxyphenyl)ethylidene)-2-phenoxynicotinic acid hydrazide

Base Information

• Chemical Name: (1-(4-methoxyphenyl)ethylidene)-2-phenoxynicotinic acid hydrazide
• CAS No.: 1254692-04-0
• Molecular Formula: C₂₁H₁₉N₃O₃
• Molecular Weight: 361.4
• Mol file: 1254692-04-0.mol

Synonyms:

Chemical Property of (1-(4-methoxyphenyl)ethylidene)-2-phenoxynicotinic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-(4-methoxyphenyl)ethylidene)-2-phenoxynicotinic acid hydrazide

There total 5 articles about (1-(4-methoxyphenyl)ethylidene)-2-phenoxynicotinic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-phenoxynicotinic acid hydrazide (175135-01-0) + 1-(4-methoxyphenyl)ethanone (100-06-1) → (1-(4-methoxyphenyl)ethylidene)-2-phenoxynicotinic acid hydrazide (1254692-04-0)

Guidance literature:

With hydrogenchloride; In ethanol; water; Reflux;

DOI:10.1002/ardp.200900294

Reference yield:

2-chloronicotinic acid (2942-59-8) → (1-(4-methoxyphenyl)ethylidene)-2-phenoxynicotinic acid hydrazide (1254692-04-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium methylate / Heating

2: sulfuric acid / 8 h / Reflux

3: hydrazine hydrate / ethanol / 2.5 h / Reflux

4: hydrogenchloride / ethanol; water / Reflux

With hydrogenchloride; sulfuric acid; sodium methylate; hydrazine hydrate; In ethanol; water;

DOI:10.1002/ardp.200900294

Reference yield:

phenol (108-95-2,27073-41-2) → (1-(4-methoxyphenyl)ethylidene)-2-phenoxynicotinic acid hydrazide (1254692-04-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium methylate / Heating

2: sulfuric acid / 8 h / Reflux

3: hydrazine hydrate / ethanol / 2.5 h / Reflux

4: hydrogenchloride / ethanol; water / Reflux

With hydrogenchloride; sulfuric acid; sodium methylate; hydrazine hydrate; In ethanol; water;

DOI:10.1002/ardp.200900294

upstream raw materials:

2-chloronicotinic acid

2-phenoxynicotinic acid hydrazide

1-(4-methoxyphenyl)ethanone

ethyl 2-phenoxypyridine-3-carboxylate

Refernces