2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one

Base Information

• Chemical Name: 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one
• CAS No.: 1255919-01-7
• Molecular Formula: C₂₆H₃₀N₆O₄S
• Molecular Weight: 522.628
• Mol file: 1255919-01-7.mol

Synonyms:

Chemical Property of 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

7-Despropyl7-PhenylVardenafil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 7-Despropyl 7-Phenyl Vardenafil is an impurity of Vardenafil (V098001), which is a selective phosphodiesterase type 5 (PDE5) inhibitor, used to treat erectile dysfunction.

Technology Process of 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one

There total 7 articles about 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H19NO5 (1393652-31-7) → 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one (1255919-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 1.5 h / 65 °C

1.2: 4 h / 60 - 80 °C

2.1: chlorosulfonic acid / 0.17 h / 0 °C

3.1: dichloromethane / 1.5 h / 25 - 30 °C

With chlorosulfonic acid; In methanol; dichloromethane;

DOI:10.1080/00397911.2011.585268

Reference yield:

2-(2-ethoxyphenyl)-5-methyl-7-phenyl-imidazo[5,1-f][1,2,4]triazin-4(3H)-one (1393652-32-8) → 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one (1255919-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 0.17 h / 0 °C

2: dichloromethane / 1.5 h / 25 - 30 °C

With chlorosulfonic acid; In dichloromethane;

DOI:10.1080/00397911.2011.585268

Reference yield:

2-ethoxy-benzamidine hydrochloride (18637-00-8) → 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-phenyl-3H-imidazo[5,1-f] [1,2,4]triazin-4-one (1255919-01-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrazine hydrate / methanol / 1.5 h / 28 °C

2.1: methanol / 1.5 h / 65 °C

2.2: 4 h / 60 - 80 °C

3.1: chlorosulfonic acid / 0.17 h / 0 °C

4.1: dichloromethane / 1.5 h / 25 - 30 °C

With chlorosulfonic acid; hydrazine hydrate; In methanol; dichloromethane;

DOI:10.1080/00397911.2011.585268

upstream raw materials:

4-ethylpiperazine

C₁₇H₁₉NO₅

2-(2-ethoxyphenyl)-5-methyl-7-phenyl-imidazo[5,1-f][1,2,4]triazin-4(3H)-one

2-ethoxy-benzamidine hydrochloride

Refernces