N-(5-bromopyrid-2-yl)formamidoxime

Base Information

• Chemical Name: N-(5-bromopyrid-2-yl)formamidoxime
• CAS No.: 382592-25-8
• Molecular Formula: C₆H₆BrN₃O
• Molecular Weight: 216.037
• Mol file: 382592-25-8.mol

Synonyms:

Chemical Property of N-(5-bromopyrid-2-yl)formamidoxime

Chemical Property:

Purity/Quality:

N-(5-Bromopyridin-2-yl)-N'-hydroxyformimidamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-bromopyrid-2-yl)formamidoxime

There total 3 articles about N-(5-bromopyrid-2-yl)formamidoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-bromo-2-pyridylamine (1072-97-5) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → N-(5-bromopyrid-2-yl)formamidoxime (382592-25-8)

Guidance literature:

5-bromo-2-pyridylamine; N,N-dimethyl-formamide dimethyl acetal; In isopropyl alcohol; for 3h; Heating;

With hydroxylamine hydrochloride; In isopropyl alcohol; at 50 ℃;

DOI:10.1002/ejoc.200500247

Reference yield: 75.0%

5-bromo-2-pyridylamine (1072-97-5) → N-(5-bromopyrid-2-yl)formamidoxime (382592-25-8)

Guidance literature:

5-bromo-2-pyridylamine; With N,N-dimethyl-formamide dimethyl acetal; In isopropyl alcohol; for 3h; Reflux;

With hydroxylamine hydrochloride; In isopropyl alcohol; at 50 ℃;

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) + hydroxylamine hydrochloride (5470-11-1) → N-(5-bromopyrid-2-yl)formamidoxime (382592-25-8)

Guidance literature:

5-bromo-2-pyridylamine; With dimethyl adipimidate dihydrochloride; In N,N-dimethyl-formamide; isopropyl alcohol; for 3h; Reflux;

hydroxylamine hydrochloride; at 50 ℃;

upstream raw materials:

5-bromo-2-pyridylamine

N,N-dimethyl-formamide dimethyl acetal

hydroxylamine hydrochloride

Downstream raw materials:

[1,2,4]triazolo[1,5-a]pyridin-6-ylboronic acid

4-(3,4-dichlorophenyl)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1,1-dimethyl-1,2,3,4-tetrahydroisoquinoline

tert-butyl 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline

Refernces

• 1、 -. "SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF". Page/Page column 86-87. . Retrieved 2010/04/03.
• 2、 -. "7-([1,2,4,]TRIAZOLO[1,5,-A]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4- TETRAHYDROISOQUINOLINE AND USE THEREOF". Page/Page column 37-38. . Retrieved 2010/12/17.