3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester

Base Information

• Chemical Name: 3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester
• CAS No.: 85580-22-9
• Molecular Formula: C₂₃H₂₁NO₆
• Molecular Weight: 407.423
• Mol file: 85580-22-9.mol

Synonyms:

Chemical Property of 3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester

There total 2 articles about 3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(4,5-dimethoxy-2-nitrophenyl)acetic acid (73357-18-3) + diazodiphenylmethane (908093-98-1) → 3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester (85580-22-9)

Guidance literature:

In dichloromethane; ethyl acetate; for 20h; Ambient temperature;

DOI:10.1248/cpb.30.4545

Reference yield:

benzophenone hydrazone (5350-57-2) → 3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester (85580-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; CH₂Cl₂ / Ambient temperature

2: 86 percent / ethyl acetate; CH₂Cl₂ / 20 h / Ambient temperature

In methanol; dichloromethane; ethyl acetate;

DOI:10.1248/cpb.30.4545

Reference yield: 97.0%

3,4-dimethoxy-2-nitrophenylacetic acid benzhydryl ester (85580-22-9) → (4,5-dimethoxy-2-nitrophenyl)acetic acid (73357-18-3)

Guidance literature:

With formic acid; at 40 - 45 ℃; for 0.5h; Product distribution;

DOI:10.1248/cpb.30.4545

upstream raw materials:

(4,5-dimethoxy-2-nitrophenyl)acetic acid

diazodiphenylmethane

benzophenone hydrazone

Downstream raw materials:

(4,5-dimethoxy-2-nitrophenyl)acetic acid

Refernces