Technology Process of (2S,5S)-2,5-diphenylhexan-3-one
There total 3 articles about (2S,5S)-2,5-diphenylhexan-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
manganese; (1,2-dimethoxyethane)dichloronickel(II); 2,6-dimethylbenzoic acid; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline);
In
tetrahydrofuran; N,N-dimethyl acetamide;
at 20 ℃;
for 24h;
Overall yield = 67 %; Overall yield = 33.7 mg; stereoselective reaction;
Molecular sieve;
Inert atmosphere;
Glovebox;
DOI:10.1021/ja402922w
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 23 °C
2: 2,6-dimethylbenzoic acid; manganese; (1,2-dimethoxyethane)dichloronickel(II); (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline) / N,N-dimethyl acetamide; tetrahydrofuran / 24 h / 20 °C / Molecular sieve; Inert atmosphere; Glovebox
With
manganese; oxalyl dichloride; (1,2-dimethoxyethane)dichloronickel(II); 2,6-dimethylbenzoic acid; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline); N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/ja402922w
- Guidance literature:
-
Multi-step reaction with 2 steps
1: thionyl chloride / chloroform / 12 h / 23 °C
2: 2,6-dimethylbenzoic acid; manganese; (1,2-dimethoxyethane)dichloronickel(II); (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline) / N,N-dimethyl acetamide; tetrahydrofuran / 24 h / 20 °C / Molecular sieve; Inert atmosphere; Glovebox
With
manganese; thionyl chloride; (1,2-dimethoxyethane)dichloronickel(II); 2,6-dimethylbenzoic acid; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline);
In
tetrahydrofuran; chloroform; N,N-dimethyl acetamide;
DOI:10.1021/ja402922w