2-(6-chloro-5-fluoro-2-oxoindolin-3-ylidene)-N-(4-chlorophenyl)hydrazine carbothioamide

Base Information

• Chemical Name: 2-(6-chloro-5-fluoro-2-oxoindolin-3-ylidene)-N-(4-chlorophenyl)hydrazine carbothioamide
• CAS No.: 1323295-78-8
• Molecular Formula: C₁₅H₉Cl₂FN₄OS
• Molecular Weight: 383.233
• Mol file: 1323295-78-8.mol

Synonyms:

Chemical Property of 2-(6-chloro-5-fluoro-2-oxoindolin-3-ylidene)-N-(4-chlorophenyl)hydrazine carbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-chloro-5-fluoro-2-oxoindolin-3-ylidene)-N-(4-chlorophenyl)hydrazine carbothioamide

There total 2 articles about 2-(6-chloro-5-fluoro-2-oxoindolin-3-ylidene)-N-(4-chlorophenyl)hydrazine carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-(p-chlorophenyl)-3-thiosemicarbazide (22814-92-2) + 6-Chloro-5-fluoro-1H-indole-2,3-dione (96202-57-2) → 2-(6-chloro-5-fluoro-2-oxoindolin-3-ylidene)-N-(4-chlorophenyl)hydrazine carbothioamide (1323295-78-8)

Guidance literature:

With acetic acid; In ethanol; for 4h; Reflux;

DOI:10.1007/s00044-010-9458-3

Reference yield:

3-chloro-4-fluorophenylamine (367-21-5) → 2-(6-chloro-5-fluoro-2-oxoindolin-3-ylidene)-N-(4-chlorophenyl)hydrazine carbothioamide (1323295-78-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; sodium sulfate

2: acetic acid / ethanol / 4 h / Reflux

With sulfuric acid; acetic acid; sodium sulfate; In ethanol;

DOI:10.1007/s00044-010-9458-3

upstream raw materials:

3-chloro-4-fluorophenylamine

4-(p-chlorophenyl)-3-thiosemicarbazide

6-Chloro-5-fluoro-1H-indole-2,3-dione

Refernces