Technology Process of 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-benzoate
There total 4 articles about 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-1,4-pregnadiene-3,6,20-trione 17-benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 71 percent / pyridine / 18 h / 70 °C
2: 58 percent / m-chloroperbenzoic acid / CHCl3 / 1 h / Ambient temperature
3: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
4: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
5: 29 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH3COOH aq. / Ambient temperature; 1.) 120 h; 2.) 4 h
With
pyridine; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium carbonate; toluene-4-sulfonic acid; acetic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
pyridine; methanol; chloroform; dimethyl sulfoxide; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 61 percent / pyridine/ CF3-COOH/ 1-cyclohexyl-3-(2-morpholinoethyl) carbodiimide metho-p-toluenesulfonate / dimethylsulfoxide; benzene / 16 h / Ambient temperature
2: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
3: 29 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH3COOH aq. / Ambient temperature; 1.) 120 h; 2.) 4 h
With
pyridine; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; sodium carbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid;
In
methanol; dimethyl sulfoxide; benzene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 75 percent / Na2CO3 / methanol / 18 h / Ambient temperature
2: 29 percent / 1.) p-toluenesulfonic acid monohydrate; 2.) 90percent CH3COOH aq. / Ambient temperature; 1.) 120 h; 2.) 4 h
With
sodium carbonate; toluene-4-sulfonic acid; acetic acid;
In
methanol;
