ethyl 2-(4-methoxyphenyl)-2-formyl acetate

Base Information

• Chemical Name: ethyl 2-(4-methoxyphenyl)-2-formyl acetate
• CAS No.: 122172-22-9
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 122172-22-9.mol

Synonyms:

Chemical Property of ethyl 2-(4-methoxyphenyl)-2-formyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-methoxyphenyl)-2-formyl acetate

There total 5 articles about ethyl 2-(4-methoxyphenyl)-2-formyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ ethyl 2-(4-methoxyphenyl)-2-formyl acetate (122172-22-9,29969-62-8) + ethyl α-formyl-p-methoxyphenyl acetate

Guidance literature:

Reference yield: 88.0%

ethyl p-methoxyphenylacetate (14062-18-1) + formic acid ethyl ester (109-94-4) → ethyl 2-(4-methoxyphenyl)-2-formyl acetate (122172-22-9,29969-62-8)

Guidance literature:

With ethanol; sodium; In diethyl ether; 1.) 0 deg C, 2 h, 2.) room temp., 14 h;

DOI:10.1021/jo00277a017

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → ethyl 2-(4-methoxyphenyl)-2-formyl acetate (122172-22-9,29969-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / concd H₂SO₄ / 18 h / Heating

2: 88 percent / sodium metal, ethanol / diethyl ether / 1.) 0 deg C, 2 h, 2.) room temp., 14 h

With ethanol; sulfuric acid; sodium; In diethyl ether;

DOI:10.1021/jo00277a017

upstream raw materials:

ethyl p-methoxyphenylacetate

formic acid ethyl ester

4-Methoxyphenylacetic acid

ethanol

Downstream raw materials:

(2R,3R)-1,7,7-trimethyl-2-(1-naphthyl)bicyclo<2.2.1>hept-3-yl 2-(4-methoxyphenyl)-3-oxopropanoate

5-(4-Methoxy-phenyl)-2-methyl-6-oxo-6H-pyran-3-carboxylic acid ethyl ester

7,8-dihydro-3-(4-methoxyphenyl)-7,7-dimethyl-6H-chromene-2,5-dione

3-(4-methoxyphenyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Refernces

• 1、 Shu, Chang,Hu, Xiao-Yan,Li, Shuai-Shuai,Yuan, Wei-Cheng,Zhang, Xiao-Mei. "Lewis base catalyzed asymmetric hydrosilylation of α-substituted β-enamino esters: Facile access to enantioenriched β2-amino esters via dynamic kinetic resolution". supporting information. p. 1879 - 1882. Retrieved 2014/08/18.
• 2、 Masurier, Nicolas,Debiton, Eric,Jacquemet, Alicia,Bussière, Antoine,Chezal, Jean-Michel,Ollivier, Anthony,Tétégan, Daté,Andaloussi, Mounir,Galmier, Marie-Joseph,Lacroix, Jacques,Canitrot, Damien,Teulade, Jean-Claude,Gaudreault, René C.,Chavignon, Olivier,Moreau, Emmanuel. "Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity". scheme or table. p. 137 - 150. Retrieved 2012/07/16.