4-Octadecylmorpholine

Base Information

• Chemical Name: 4-Octadecylmorpholine
• CAS No.: 16528-77-1
• Molecular Formula: C22H45 N O
• Molecular Weight: 339.605
• Hs Code.: 2934999090
• European Community (EC) Number: 240-595-6
• DSSTox Substance ID: DTXSID30167877
• Nikkaji Number: J285.800B
• Wikidata: Q83037373
• Mol file: 16528-77-1.mol

Synonyms:4-Octadecylmorpholine;16528-77-1;Morpholine, 4-octadecyl-;EINECS 240-595-6;Morpholine,4-octadecyl-;stearylmorpholin;4-Octadecylmorpholine #;SCHEMBL121880;DTXSID30167877;MFCD00224838;AKOS024331265;AS-58078

Chemical Property of 4-Octadecylmorpholine

Chemical Property:

• Vapor Pressure: 2.06E-07mmHg at 25°C
• Melting Point: 25 °C
• Boiling Point: 424.5°Cat760mmHg
• PKA: 7.61±0.10(Predicted)
• Flash Point: 124.4°C
• PSA: 12.47000
• Density: 0.87g/cm³
• LogP: 6.51800
• XLogP3: 8.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 17
• Exact Mass: 339.350115059
• Heavy Atom Count: 24
• Complexity: 238

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCCCCN1CCOCC1

Technology Process of 4-Octadecylmorpholine

There total 5 articles about 4-Octadecylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(1-oxooctadecyl)morpholine (5299-54-7) → N-octadecyl-morpholine (16528-77-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Yield given; 1) 0-5 deg C, 30 min, 2) room temperature, 2 h;

DOI:10.1021/ac00124a037

Reference yield:

Stearoyl chloride (112-76-5) → N-octadecyl-morpholine (16528-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (C₂H₅)3N / tetrahydrofuran / 1 h / 0 °C

2: LiAlH₄ / diethyl ether / 1) 0-5 deg C, 30 min, 2) room temperature, 2 h

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ac00124a037

Reference yield:

3-oxa-1,5-dichloropentane (111-44-4) + 1-aminooctadecane (124-30-1) → N-octadecyl-morpholine (16528-77-1)

Guidance literature:

DOI:10.1021/ja01642a071

upstream raw materials:

morpholine

n-iodooctadecane

1-Bromooctadecane

3-oxa-1,5-dichloropentane

Refernces

• 1、 Oesch, Urs,Brzozka, Zbigniew,Xu, Aiping,Rusterholz, Bruno,Suter, Gabriela,et al.. "Design of Neutral Hydrogen Ion Carriers for Solvent Polymeric Membrane Electrodes of Selected pH Range". . p. 2285 - 2289. Retrieved 2007/10/02.